Resistance and conduit arteries following converting enzyme inhibition in hypertension

Journal of Vascular Research
M E SafarH A Struijker-Boudier

Abstract

Alterations in the structure of resistance and conduit arteries are a characteristic hallmark in hypertension. Studies carried out in hypertensive rats and in humans suggest that angiotensin I-converting enzyme inhibition has an effect on arterial structure of resistance arteries. In hypertensive rats the reduction of the media to lumen ratio is dose-dependent and significantly different from the effects of other antihypertensive agents at doses causing an equal degree of blood pressure reduction. In large conduit arteries, hypertrophy of the vessels is reversed by converting enzyme inhibition both in hypertensive rats (studies on central arteries) and in human (studies on peripheral arteries) hypertension. The reduction of hypertrophy is associated with a decrease in arterial stiffness, partly independent of blood pressure reduction. These findings suggest that regression of structural vascular changes may contribute to both the decrease in the arteriolar resistance and the improvement in the buffering function of large arteries. The decrease in arteriolar resistance and the improvement of large artery compliance may participate in blood pressure reduction and an improvement in pulse pressure amplification produced by converti...Continue Reading

Citations

Apr 25, 2007·Hypertension·Gary F MitchellUNKNOWN Prevention of Events With Angiotensin-Converting Enzyme Inhibition Investigators
Dec 25, 2009·Journal of Atherosclerosis and Thrombosis·Takuro KubozonoChuwa Tei
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Vasiliki KatsiIoannis Kallikazaros
Jul 16, 2013·Journal of the American Society of Hypertension : JASH·Rebecca ChesterThomas Giles
Jan 22, 2008·European Journal of Internal Medicine·N R RoblesUNKNOWN Investigators of ESTEPP Study
Jan 13, 2004·Journal of the American College of Cardiology·Gérard M LondonUNKNOWN REASON Project Investigators
Aug 24, 2016·The Journal of Clinical Hypertension·Fragiskos ParthenakisPanos Vardas
Dec 16, 2005·The American Journal of Chinese Medicine·Hung-Che ShihTakeshi Shibuya
Feb 27, 2003·Cephalalgia : an International Journal of Headache·J N de HoonL M van Bortel
Aug 20, 2004·Journal of Human Hypertension·G S Stergiou
Dec 15, 2004·Hypertension·Rachel P WildmanKim Sutton-Tyrrell
Oct 16, 2004·Stroke; a Journal of Cerebral Circulation·Konstantinos N VemmosKonstantinos Spengos
Apr 11, 2019·Journal of the American Heart Association·George C Roush
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·G F Mitchell
Sep 29, 1999·Current Opinion in Cardiology·G F Mitchell, M A Pfeffer
Jun 18, 2004·Journal of Hypertension·Erwan BozecHubert Dabiré
Jul 22, 2014·The Journal of Pharmacy and Pharmacology·Kulbhushan SharmaGoutam Rath
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Silvia G LageMark A Creager
May 23, 2002·American Journal of Hypertension·Stéphane LaurentHarry Struijker-Boudier
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Edward W Inscho
Jan 27, 2005·Nursing & Health Sciences·Julia Wong, Shirley Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.