Resistance and Overcoming Resistance in Breast Cancer

Breast Cancer : Targets and Therapy
Andrea Luque-BolivarMilena Rondón-Lagos

Abstract

The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.

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Citations

Feb 10, 2021·International Journal of Molecular Sciences·Elif Damla ArisanPinar Uysal-Onganer

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT01339442
NCT01610284
NCT01437566
NCT02512237
NCT03255070
NCT02952729
NCT03671044

Software Mentioned

GLOBOCAN
DOC

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