Resistance and susceptibility to infection in inbred murine strains. II. Variations in the effect of treatment with thymosin fraction 5 on the release of lymphokines in vivo

Cellular Immunology
R Neta, S B Salvin

Abstract

Of nine inbred murine strains sensitized intravenously with killed lyophilized Candida albicans and challenged 3 weeks later with a C. albicans filtrate, four strains were low responders and five were high responders in the in vivo release of migration inhibitory factor (MIF) and gamma interferon (IFN-gamma). An identical distribution of high- and low-responder strains occurred in response to sensitization with Mycobacterium bovis BCG and subsequent challenge with old tuberculin. Treatment of the murine strains with thymosin fraction 5 prior to sensitization and challenge had different effects: (a) the high-responder strains had a decrease in their release in vivo of the two lymphokines; (b) three of five of the low-responder strains had a striking increase in the in vivo release of MIF and IFN-gamma; and (c) one low-responder strain did not have its response altered. A parallelism existed between the capacity of a murine strain to release the two lymphokines in vivo on stimulation with C. albicans antigens and the capacity of that strain to resist intravenous infection with living C. albicans.

References

Jun 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·P JamesonS E Grossberg

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Citations

Jun 12, 1985·Journal of Immunological Methods·F E WellerP H Naylor
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J CaldarellaB L Horecker
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M M ZatzA L Goldstein
Dec 1, 1995·Microbiological Reviews·R B Ashman, J M Papadimitriou
Sep 1, 1991·Infection and Immunity·D L BrawnerS Nonoyama
Mar 1, 1992·Infection and Immunity·D W Beno, H L Mathews

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