PMID: 11900957Mar 20, 2002Paper

Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance

Veterinary Microbiology
Aouatef DjerabaPascale Quéré

Abstract

The metabolic NO pathway, catalyzed by the enzyme NO synthase in macrophages, is a key defense element against viruses and tumors. However, arginase is an other enzyme able to metabolize the substrate L-arginine, and the two enzymes are alternatively regulated by Th1 and Th2 cytokines in murine macrophages. Marek's disease is characterized by strong immunosuppression and development of T-cell lymphomas in chickens. Inoculation of the very virulent strain of MDV RB-1B induced strong and long-lasting arginase macrophage-dependent activity, which was inhibited by L-norvaline in vitro, but induced low NO production in monocytes and splenocytes from highly susceptible B(13)/B(13) chickens. By contrast, in B(21)/B(21) chickens genetically resistant to tumor development, RB-1B induced a weak and transient increase in arginase activity and strong NO production. The vaccinal HVT strain did not induce any arginase activity in monocytes or splenocytes. Moreover, vaccination with HVT prevented tumor appearance after RB-1B challenge and increase in arginase activity, but favored NO production in susceptible chickens. Differential expression of NO synthase and arginase was modulated in chicken macrophages, with IFN-gamma and LPS being strong...Continue Reading

References

May 15, 1979·International Journal of Cancer. Journal International Du Cancer·K HafferM Wilder
Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·H Kadowaki, M C Nesheim
Mar 1, 1991·Immunology Today·F Y Liew, F E Cox
Jul 1, 1989·Veterinary Microbiology·M K GuptaK K Singh
Sep 1, 1987·Veterinary Immunology and Immunopathology·J M Bumstead, L N Payne
Jan 1, 1969·European Journal of Biochemistry·N Rossi, E Grazi
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J W LowenthalJ J York
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M R Digby, J W Lowenthal
May 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C P JenkinsonS D Cederbaum
May 1, 1997·Trends in Biotechnology·N van RooijenA Sanders
May 1, 1998·Immunobiology·S H JeurissenE Claassen
Mar 16, 2000·Developmental and Comparative Immunology·K A Schat, Z Xing
Jan 1, 1982·Avian Pathology : Journal of the W.V.P.A·K A SchatJ Fabricant

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Citations

Apr 25, 2008·Viral Immunology·Mohammad HeidariShayan Sharif
Sep 25, 2014·Frontiers in Immunology·Kristina S Burrack, Thomas E Morrison
Oct 24, 2014·Frontiers in Immunology·Anita C Thomas, Joshua T Mattila
Nov 19, 2020·Animals : an Open Access Journal From MDPI·Fernanda Lima de Souza Castro, Woo K Kim
Feb 9, 2010·Developmental and Comparative Immunology·Niroshan Thanthrige-DonShayan Sharif

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