Resistance exercise reduces muscular substrates in women

International Journal of Sports Medicine
M P HarberW F Fink

Abstract

The purpose of this investigation was to examine the influence of an acute bout of resistance exercise (RE) on intramuscular triglyceride (IMTG) and muscle glycogen concentrations and intracellular signaling in women with high body fat content. Six overweight women with a high percent body fat (age 29+/-3 yr; BMI 28+/-3 kg/m(2), body fat 38+/-4%) performed 6 sets of 10 repetitions of knee extension exercise at 70% 1RM. Muscle biopsies were obtained from the vastus lateralis before, 1 min after (POST1), and 2 h after (POST2) exercise. Acute RE reduced (p<0.05) IMTG content approximately 40% at POST1 and POST2 (75+/-5; 45+/-6; 50+/-10 mmol/kg/dry wt). Muscle glycogen was also reduced (p<0.05) approximately 25% at POST1 and remained lower at POST2 (317+/-14; 241+/-30; 235+/-26 mmol/kg/dry wt). ERK1/2, SAPK/JNK, and p38 phosphorylation were increased (p<0.05) approximately 2-3-fold at POST1 and ERK1/2 remained elevated and POST2 whereas SAPK/JNK and p38 returned to basal levels. AMPKalpha phosphorylation was unchanged in response to RE. These results show that both IMTG and muscle glycogen stores serve as an important energy source during RE in overweight women and the MAP kinase signaling response to RE is not compromised by high ...Continue Reading

Citations

Dec 23, 2008·European Journal of Nutrition·Stéphanie A BayolNeil C Stickland
Mar 8, 2011·European Journal of Applied Physiology·Christopher S ShawAnton J M Wagenmakers
Nov 19, 2010·International Journal of Sports Medicine·J S WootenJ J Barbee
Nov 13, 2012·Journal of Medicinal Food·Gabrielle Aparecida CardosoCarlos Mario Donado-Pestana
Apr 9, 2010·Annual Review of Nutrition·Christopher S ShawAnton J M Wagenmakers
Jul 23, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam R KonopkaMatthew P Harber
Sep 20, 2011·European Journal of Applied Physiology·Teresa FuentesJose A L Calbet
Sep 25, 2012·Mechanisms of Ageing and Development·Mengyao LiNicolas Musi
Jan 1, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Matthew HinkleyMatthew P Harber
Jun 15, 2021·BMC Sports Science, Medicine and Rehabilitation·Guillermo EscalanteBrad J Schoenfeld

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