Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.

Journal of Applied Physiology
Tatiana MoroChristopher S Fry

Abstract

Aging induces physiological decline in human skeletal muscle function and morphology, including type II fiber atrophy and an increase in type I fiber frequency. Resistance exercise training (RET) is an effective strategy to overcome muscle mass loss and improve strength, with a stronger effect on type II fibers. In the present study, we sought to determine the effect of a 12-wk progressive RET program on the fiber type-specific skeletal muscle hypertrophic response in older adults. Nineteen subjects [10 men and 9 women (71.1 ± 4.3 yr)] were studied before and after the 12-wk program. Immunohistochemical analysis was used to quantify myosin heavy chain (MyHC) isoform expression, cross-sectional area (CSA), satellite cell abundance, myonuclear content, and lipid droplet density. RET induced an increase in MyHC type II fiber frequency and a concomitant decrease in MyHC type I fiber frequency. Mean CSA increased significantly only in MyHC type II fibers (+23.3%, P < 0.05), but myonuclear content increased only in MyHC type I fibers (P < 0.05), with no change in MyHC type II fibers. Satellite cell content increased ~40% in both fiber types (P > 0.05). RET induced adaptations to the capillary supply to satellite cells, with the dista...Continue Reading

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Citations

Sep 4, 2020·Journal of Cachexia, Sarcopenia and Muscle·Kevin A MurachCory M Dungan
Apr 1, 2021·Journal of Cachexia, Sarcopenia and Muscle·Knut Sindre MølmenStian Ellefsen
Apr 4, 2021·International Journal of Molecular Sciences·Robert SolsonaAnthony Mj Sanchez
Sep 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin A MurachCharlotte A Peterson

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Fiji
GraphPad Prism
AxioVision Rel

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