Resistance gene transfer in anaerobes: new insights, new problems

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Abigail A Salyers, Nadja Shoemaker

Abstract

Investigations of antibiotic-resistance gene transfer elements in Bacteroides species have generated some new insights into how bacteria transfer resistance genes and what environmental conditions foster gene transfer. Integrated gene transfer elements, called conjugative transposons, appear to be responsible for much of the transfer of resistance genes among Bacteroides species. Conjugative transposons not only transfer themselves but also mobilize coresident plasmids and excise and mobilize unlinked integrated elements. Less is known about resistance gene transfer elements of the gram-positive anaerobes, but there are some indications that similar elements may be found in them as well. An unusual feature of the Bacteroides conjugative transposons is that transfer of many of them is stimulated considerably by low concentrations of antibiotics. Thus, antibiotics not only select for resistant strains but also can stimulate transfer of the resistance gene in the first place. This finding raises questions about whether use of low-dose tetracycline therapy may have a greater effect on the resident microflora than had been previously thought. Finally, investigations of resistance genes in Bacteroides species and other genera of bact...Continue Reading

Citations

Jul 12, 2001·Research in Microbiology·V C Nwosu
May 5, 2000·International Journal of Antimicrobial Agents·W Witte
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hannah M Wexler
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Sonja LöfmarkCharlotta Edlund
May 27, 2005·Antimicrobial Agents and Chemotherapy·Patrizia SpigagliaPaola Mastrantonio
Aug 12, 2009·Applied and Environmental Microbiology·Joanna BoguslawskaJacek Bardowski
Jul 10, 2007·Applied and Environmental Microbiology·Jeannette Muñoz-AguayoRandall S Singer
Jul 6, 2000·Applied and Environmental Microbiology·A M HohnstockE L Madsen
Jul 27, 2001·Applied and Environmental Microbiology·G WhittleA A Salyers
May 7, 2009·Future Microbiology·Gayatri Vedantam
Feb 26, 2016·Revista de gastroenterología de México·J M Remes Troche
Jun 28, 2011·Veterinary Microbiology·Anne-Mette R GrønvoldRoderick I Mackie
Sep 10, 2010·Anaerobe·Gena D TribbleCharles J Smith
May 7, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Edlund, C E Nord
Feb 14, 2006·Trends in Microbiology·Jean-Pierre LiautardStephan Köhler
Jan 24, 2006·International Journal of Antimicrobial Agents·Jonathan G FryePaula J Fedorka-Cray
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Guido WernerWolfgang Witte
Nov 3, 2004·The Veterinary Clinics of North America. Equine Practice·David A Dargatz, Josie L Traub-Dargatz
Jun 30, 2000·Plasmid·N TavakoliP Bennett
Jun 6, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C E NordD M Grasela
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Margaret J Duncan
Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·W O ChungM C Roberts
Feb 25, 2017·Probiotics and Antimicrobial Proteins·Svetoslav Dimitrov TodorovLuís Augusto Nero
Jul 11, 2000·The Veterinary Record·E Mateu, M Martín

❮ Previous
Next ❯

Related Concepts

Related Feeds

ABC Transporters & Multidrug Resistance

ABC Transporters or ATP-Binding Cassette Transporters are responsible for pumping out antibiotics in the cell and can lead to multidrug resistance in bacteria. Discover the latest research on ABC Transporters & Multidrug Resistance here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
S A ClayH Kennouche
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
E Collatz
© 2021 Meta ULC. All rights reserved