Resistance is futile: antineuronal autoimmunity in multiple sclerosis

Trends in Immunology
Ruth HuizingaSandra Amor

Abstract

For many years, loss of myelin was considered to be the major cause of neurological dysfunction in multiple sclerosis (MS), a chronic inflammatory, demyelinating disease of the central nervous system. This 'myelinocentric' view of MS was revised recently, after recognition that axonal damage, rather than demyelination, provides a better correlate to clinical symptoms. Nonetheless, current views of MS pathogenesis remain focused on the role of myelin-specific autoimmunity, and the potential contribution of autoimmune responses to axonal and neuronal antigens is ignored. Drawing on experience gained from work with other neurodegenerative diseases, we hypothesize that autoimmunity, particularly pathogenic antibodies to neuronal and axonal antigens, plays a significant role in the development of axonal pathology in MS. This concept offers a new perspective of disease pathogenesis and therapeutic approaches to prevent irreversible axonal loss and chronic disability in MS.

References

Jan 1, 1984·Annals of the New York Academy of Sciences·T EndoD M Marcus
Mar 2, 1999·Brain : a Journal of Neurology·D KiddT Revesz
May 29, 2000·Brain : a Journal of Neurology·A BitschW Brück
Apr 19, 2002·Journal of Neuroimmunology·Margaret M Morris-DownesSandra Amor
Jan 23, 2003·Brain : a Journal of Neurology·Roberto FurlanGianvito Martino
Jul 24, 2003·Brain : a Journal of Neurology·Gareth PryceDavid Baker
Mar 24, 2004·Trends in Immunology·Hans Lassmann, Richard M Ransohoff
May 19, 2004·Neuroscience Letters·Anette StorsteinChristian Vedeler
Jan 25, 2005·Neurochemical Research·George H DeVries
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R OmdalS I Mellgren
May 17, 2005·Journal of the Neurological Sciences·Alexandra Kutzelnigg, Hans Lassmann
Jul 13, 2005·Acta Neurologica Scandinavica·J I EngelhardtL Siklós
Aug 16, 2005·Journal of Neuroimmunology·Yiping ZhangYufen Qin
Aug 18, 2005·Journal of Neuroimmunology·Sandra AmorDavid Baker
Sep 13, 2005·Trends in Immunology·Lawrence Steinman, Scott S Zamvil
Oct 13, 2005·Brain : a Journal of Neurology·Carolyn F OrrGlenda M Halliday
Apr 25, 2006·Nature Medicine·Yawei LiuShohreh Issazadeh-Navikas
Apr 26, 2006·Brain : a Journal of Neurology·Manuel A FrieseLars Fugger
Apr 28, 2006·Acta Neurologica Scandinavica. Supplementum·L BöP van der Valk
Jun 14, 2006·Seminars in Oncology·Robert B Darnell, Jerome B Posner
Aug 29, 2006·Journal of Neuroimmunology·Jack Antel, Amit Bar-Or
Oct 13, 2006·Archives of Neurology·Hanna RosenmannOded Abramsky
Nov 30, 2006·Trends in Immunology·Ian GaleaV Hugh Perry
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helmar C LehmannKazim A Sheikh
Apr 4, 2007·The Journal of Biological Chemistry·Robert KirmseJörg Langowski
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Ruth HuizingaSandra Amor
Apr 17, 2007·Journal of Clinical Immunology·Farzin ForooghianHans-Michael Dosch

❮ Previous
Next ❯

Citations

May 9, 2012·Brain : a Journal of Neurology·Christina ElliottChristopher Linington
Feb 26, 2009·International Immunology·Ruth HuizingaSandra Amor
Dec 4, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marloes van ZwamLeonie A Boven
Jan 21, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Peter K Stys
May 2, 2013·Journal of Neuroimmunology·Lenka FialováJolana Kotoucova
Jan 10, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Gehan Ahmed Mostafa, Laila Yousef Al-Ayadhi
Aug 13, 2015·Human Vaccines & Immunotherapeutics·Giovanna VitalitiRaffaele Falsaperla
Apr 28, 2009·Autoimmunity Reviews·Klaartje SomersVeerle Somers
Sep 23, 2008·Neurobiology of Disease·Ruth HuizingaSandra Amor
Jun 22, 2010·Immunology·Sandra AmorPaul van der Valk
Oct 30, 2016·Brain Pathology·Markus KippSandra Amor
Aug 15, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Graham R CampbellDon J Mahad
Jun 4, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tamara Vyshkina, Bernadette Kalman
Aug 15, 2009·Journal of Neuropathology and Experimental Neurology·Chandra DebCharles L Howe
Apr 30, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Libuse NoskovaTomas Zima
Jul 4, 2018·Journal of Alzheimer's Disease : JAD·Ales BartosJana Švarcová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.