Resistance of cholestatic rats against epinephrine-induced arrhythmia: the role of nitric oxide and endogenous opioids

European Journal of Pharmacology
Amir Reza HajrasoulihaAhmad R Dehpour

Abstract

Short-term ligation of bile duct has been used as a model to study acute cholestasis and is associated with various cardiovascular abnormalities. We examined the role of nitric oxide (NO) and endogenous opioids on epinephrine-induced arrhythmia in 7-day bile duct-ligated (BDL) rats. Six groups of rats, each of which was subdivided into two subgroups (sham-operated and BDL), were examined. First group of animals were chronically treated with normal saline. In the second and third groups, single intraperitoneal administration of N(omega)-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg) or naltrexone (20 mg/kg) was performed 30 min before evaluation of epinephrine-induced arrhythmia. Two groups received chronic administration of low dose (3 mg/kg/day) or high dose (10 mg/kg/day) L-NAME; and the last group was treated chronically with naltrexone (20 mg/kg/day). Chronic drug administration was performed subcutaneously for 6 consecutive days following BDL or sham operation. After induction of arrhythmia by intravenous injection of 10 microg/kg epinephrine, mean arterial pressure and electrocardiogram were recorded for 1 min. Heart rate and mean arterial pressure were significantly lower in BDL rats (P<0.01). Chronic injection of nalt...Continue Reading

References

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Feb 7, 2003·Fundamental & Clinical Pharmacology·Seyed Ali GaskariAhmad Reza Dehpour
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Citations

Apr 24, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Leila Moezi, Ahmad R Dehpour
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Hamed ShafaroodiAhmad Reza Dehpour
Jul 11, 2006·European Journal of Pharmacology·Sina TavakoliAhmad Reza Dehpour
Mar 3, 2006·Journal of Hepatology·Andrea ZambruniMauro Bernardi
Oct 18, 2005·European Journal of Pharmacology·Farzad EbrahimiAhmad Reza Dehpour
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein

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