Resistance of early midgut stages of natural Plasmodium falciparum parasites to high temperatures in experimentally infected Anopheles gambiae (Diptera: Culicidae)

The Journal of Parasitology
Bernard A OkechJohn I Githure

Abstract

We studied the effects of high temperature, 30 and 32 versus 27 C on early Plasmodium falciparum development in Anopheles gambiae experimentally infected with gametocytes from 30 volunteers with mean density of 264.1 gametocytes/microl blood (range: 16-1,536/microl). From several batches of mosquitoes, fed by membrane feeding, midguts of individual mosquitoes were dissected at 24 hr for ookinete enumeration and at 7 days to quantify oocysts. There were temperature-related differences in mean ookinete intensity per mosquito midgut, with 9.71 +/- 1.6 at 27 C, 9.85 +/- 2.32 at 30 C, and 3.89 +/- 0.81 at 32 C. The prevalence of oocyst infection decreased with an increase in temperatures from 15.9 to 8.5 to 6.4% at 27, 30, and 32 C, respectively. The average oocyst intensities for the infected mosquitoes increased with temperatures from 2.9 at 27 C to 3.5 at 30 C, and to 3.3 at 32 C. However, the success of infections was reduced at 30 and 32 C, and resulted in greater losses during consecutive inter-stage parasite development. The most significant impact of high temperatures occurred at the transition between macrogametocytes and ookinetes, whereas the transition between ookinetes and oocysts apparently was not affected. In contras...Continue Reading

References

Jul 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A K GithekoF H Collins
Jul 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·B KhanS K Martin
Jul 1, 1992·The American Journal of Tropical Medicine and Hygiene·J C BeierJ A Vaughan
Sep 1, 1994·Molecular and Biochemical Parasitology·S BonnefoyO Mercereau-Puijalon
Aug 1, 1994·The American Journal of Tropical Medicine and Hygiene·J A VaughanJ C Beier
Feb 16, 2000·The American Journal of Tropical Medicine and Hygiene·N MinakawaG Yan
May 25, 2001·Journal of Medical Entomology·N MinakawaG Yan
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·H P Awono-AmbeneV Robert
May 1, 1954·Transactions of the Royal Society of Tropical Medicine and Hygiene·R C MUIRHEAD-THOMSON

❮ Previous
Next ❯

Citations

Jul 3, 2013·PLoS Pathogens·Thierry LefèvreAnna Cohuet
Jun 26, 2008·The Journal of Parasitology·Shreekanta S PoudelJefferson A Vaughan
Jun 10, 2014·Journal of Insect Physiology·Courtney C MurdockMatthew B Thomas
Sep 21, 2013·Proceedings. Biological Sciences·Courtney C MurdockMatthew B Thomas
Dec 26, 2006·Trends in Parasitology·Jefferson A Vaughan
Apr 22, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·I SangareA Cohuet
Nov 14, 2012·Nature Reviews. Microbiology·Courtney C MurdockMatthew B Thomas
Apr 25, 2018·Journal of Mathematical Biology·Steffen E Eikenberry, Abba B Gumel

❮ Previous
Next ❯

Methods Mentioned

BETA
dissections

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.