PMID: 9440053Jan 24, 1998Paper

Resistance of Helicobacter pylori to macrolides and nitroimidazole compounds. The current situation

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
F MégraudH P Doermann

Abstract

Macrolides and nitroimidazoles are among the antibiotics currently used for Helicobacter pylori eradication for which an acquired resistance may occur. Macrolides bind tightly to H. pylori ribosomes and inhibit protein synthesis. Resistance has been found associated with a lack of binding and to a point mutation in position 2058 or 2059 of the 23S ribosomal RNA genes (domain V). This resistance is easy to detect and is clinically relevant. There is a decrease of up to 40% in the success rate of triple therapies including clarithromycin when there is a resistance of H. pylori to this compound. Nitroimidazoles must be reduced to be active on the bacterial DNA. Resistance is associated with a lack of reduction of the NO2 group. But this reduction can be influenced by the redox potential of the environment. The genetic background is not yet known. There are discrepancies between the different methods used to test susceptibility to nitroimidazole; the best method which is now in the process of being standardized, is the agar dilution method. The clinical relevance of this resistance has been questioned. However, despite all the problems highlighted, there is still a difference between strains categorized as susceptible or resistant ...Continue Reading

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.