PMID: 7939324Apr 15, 1994Paper

Resistance of pneumococcus

La Revue du praticien
F W Goldstein

Abstract

Resistance of S. pneumoniae to penicillin G and other useful antibiotics has sharply increase during the last years in many countries and especially in France. Resistance to penicillin G is due to an unpredictable qualitative and quantitative modification of several penicillin binding proteins. All the beta-lactams are affected but the level of cross-resistance depends upon the affinity of the beta-lactam for the modified penicillin binding proteins. As a consequence, the minimal inhibitory concentration of penicillin G and other useful beta-lactams have to be determined against S. pneumoniae isolated from serious infection, responsible for a clinical failure or resistant to penicillin G.

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