PMID: 9655535Jul 9, 1998Paper

Resistance pattern of middle ear fluid isolates in acute otitis media recently treated with antibiotics

The Pediatric Infectious Disease Journal
E LeibovitzR Dagan

Abstract

Little information is available about the effect of antibiotic treatment on the prevalence and MIC of the subsequently isolated pathogens in cases of acute otitis media (AOM) failing a course of antibiotic therapy. This information is important, particularly regarding the effectiveness of the oral antibiotics used in children failing initial therapy. One hundred eighty-one children with culture-positive AOM were prospectively studied between October, 1995, and July, 1996. Sixty-three (35%) patients received various antibiotics for variable periods during the 14 days preceding enrollment. A total of 94 Streptococcus pneumoniae (Pnc) and 113 Haemophilus influenzae (Hi) were isolated. Thirty-eight Pnc and 35 Hi were isolated in the 63 patients with recently treated AOM. Pnc as a single isolate was more prevalent in patients recently treated with antibiotics (27 of 63, 43%) than among those not recently treated (32 of 118, 27%, P = 0.047). The MIC50 values of penicillin, cefaclor and cefuroxime axetil for Pnc were significantly higher in the pneumococci isolated from patients recently treated than among those isolated from patients not recently treated with antibiotics (0.38, 3 and 0.75 microg/ml vs. 0.094, 0.38 and 0.12 microg/ml,...Continue Reading

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Citations

May 31, 2008·Current Infectious Disease Reports·Eugene Leibovitz
Dec 4, 2003·International Journal of Pediatric Otorhinolaryngology·Joseph Dohar
Sep 28, 2000·International Journal of Pediatric Otorhinolaryngology·K Roos, P Larsson
Nov 22, 2002·International Journal of Pediatric Otorhinolaryngology·E Lee Ford-JonesUNKNOWN Members of the Toronto Antibiotic Resistance at Myringotomy Study Group
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·A LeibermanD M Fliss
Feb 13, 2001·Vaccine·G S Giebink
Aug 5, 2000·International Journal of Antimicrobial Agents·E Leibovitz, R Dagan
Jan 7, 1999·The Pediatric Infectious Disease Journal·E LeibovitzR Dagan
Oct 26, 1999·The Pediatric Infectious Disease Journal·L C Olson, M A Jackson
Oct 26, 1999·The Pediatric Infectious Disease Journal·P H HendolinJ Ylikoski
May 20, 2000·The Pediatric Infectious Disease Journal·D Musher, R Dagan
Jan 6, 2001·The Pediatric Infectious Disease Journal·S L BlockK J Tack
Jan 6, 2001·The Pediatric Infectious Disease Journal·S L BlockUNKNOWN Cefdinir Otitis Media Study Group
Dec 6, 2001·The Pediatric Infectious Disease Journal·S L BlockC J Harrison
Jun 7, 2003·The Pediatric Infectious Disease Journal·Lolita PiglanskyRon Dagan
Jun 12, 2003·The Pediatric Infectious Disease Journal·Eugene LeibovitzRon Dagan
Oct 11, 2003·The Pediatric Infectious Disease Journal·Anna KatzRon Dagan
Nov 14, 2003·The Pediatric Infectious Disease Journal·Adriano ArguedasPhillip F Pierce
Dec 23, 2003·The Pediatric Infectious Disease Journal·Adriano ArguedasMarco Luis Herrera
Jan 25, 2005·The Pediatric Infectious Disease Journal·Philip ToltzisJeffrey L Blumer
Dec 16, 2009·The Pediatric Infectious Disease Journal·Stephen I Pelton, Eugene Leibovitz
Jul 8, 2000·Pediatric Annals·J W Ogle
Mar 14, 2009·Vaccine·Eugene Leibovitz
Jun 15, 2007·Infectious Disease Clinics of North America·Itzhak Brook
Mar 26, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Noa Shviro-RosemanEugene Leibovitz
Nov 9, 2006·Advances in Pediatrics·Stephen J Barenkamp
Aug 17, 2005·Infectious Disease Clinics of North America·Philip Toltzis, Michael R Jacobs
Aug 9, 2002·Clinical Pediatrics·Alejandro HobermanSandor Feldman
Jan 30, 2010·Expert Review of Anti-infective Therapy·Eugene LeibovitzNitza Newman

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