Resistance reversal action of ketoconazole against mefloquine resistance of Plasmodium yoelii nigeriensis

Experimental Parasitology
A AwasthiRenu Tripathi

Abstract

Ketoconazole at 200 mg/kg dose has been found to exert marginal antimalarial action against multidrug resistant (MDR) Plasmodium yoelii nigeriensis (P. yoelii nigeriensis) in Swiss mice with 25% protection (2/8 mice) while at lower Ketoconazole dose i.e., 75-100 mg/kg, 14.28% mice were protected. Mefloquine (MFQ) (at 8 and 16 mg/kg) exerted suppressive action against MDR P. yoelii nigeriensis resulting in 25 and 14.28% protection of mice respectively. Combined treatment with Ketoconazole and mefloquine resulted in protection of 5/6 mice (83.33%) at MFQ 4 mg/kg + Ketoconazole 100 mg/kg dose, 7/8 (87.5%) mice at MFQ 8 mg/kg + Ketoconazole 20 mg/kg dose and 5/7 (71.42%) mice at MFQ 16 mg/kg + Ketoconazole 25 mg/kg dose and 5/6 (83.33%) mice at MFQ 16 mg/kg + Ketoconazole 100 mg/kg dose. Ketoconazole has been found to enhance the protective effect of mefloquine against MFQ resistant P. yoelii nigeriensis resulting in 66-88% protection of the mice treated with the appropriate combinations. The combination also increased suppression of parasitaemia at different times. The Ketoconazole combination with MFQ significantly increased the mean survival time of the treated mice compared to individual drugs alone. The study shows that Ketoco...Continue Reading

Citations

Nov 10, 2012·Parasitology·Swaroop Kumar PandeyRenu Tripathi
Jun 16, 2007·Experimental Parasitology·Kesara Na-BangchangSteven A Ward
Jun 6, 2009·Acta Tropica·Raewadee WisedpanichkijKesara Na-Bangchang
Mar 19, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mattia Müller, Patricia Schlagenhauf
Mar 18, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Juan Ricardo RodriguesNeira Gamboa
Dec 18, 2018·Psychophysiology·Gary G Berntson

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