Resistance to a triple-combination anthelmintic in Trichostrongylus spp. on a commercial sheep farm in New Zealand

New Zealand Veterinary Journal
Bas Hodgson, C J Mulvaney

Abstract

To evaluate resistance to anthelmintics containing abamectin, levamisole, and oxfendazole (AB-LEV-OX), derquantal and abamectin (DEQ-AB), moxidectin, and monepantel in naturally acquired gastrointestinal nematodes present on a sheep farm. Faecal nematode egg count reduction tests (FECRT) were carried out on lambs that were approximately 7 months-old and infected with naturally acquired nematodes. Lambs were randomly allocated to one of five groups (n=15 per group): treatment with 2 mg/kg derquantel and 0.2 mg/kg abamectin; 0.2 mg/kg abamectin, 8 mg/kg levamisole HCl and 4.5 mg/kg oxfendazole; 2.5 mg/kg monepantel; 0.2 mg/kg moxidectin, or no treatment. Post-treatment samples were collected 12 days later. Abomasa and small intestines were collected from two slaughtered lambs from each of the DEQ-AB, AB-LEV-OX, moxidectin and control groups 15 days after treatment, for nematode counting. The FECRT demonstrated that efficacy was 90.3 (95% CI=84.2-94.1)% for AB-LEV-OX, 54.5 (95% CI=28.4-71.1)% for moxidectin, 99.2 (95% CI=97.4-99.8)% for DEQ-AB and 100% for monepantel, across all genera. For Trichostrongylus spp. efficacy was 85.5% for AB-LEV-OX and 46.7% for moxidectin. Haemonchus spp. were fully susceptible to all treatments. Pos...Continue Reading

References

Jul 21, 2005·New Zealand Veterinary Journal·A VlassoffA C Heath
Oct 12, 2007·New Zealand Veterinary Journal·K E LawrenceJ R Moffat
Jan 17, 2012·Veterinary Parasitology·David J BartramSteven J Maeder

❮ Previous
Next ❯

Citations

Nov 6, 2018·Frontiers in Veterinary Science·Fiona Vande VeldeEdwin Claerebout
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Néstor RomeroÁngel Céspedes
Aug 9, 2019·Experimental Parasitology·Jessica Maria Leite Dos SantosJomar Patrício Monteiro

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

FECRT

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.