Resistance to activated protein C: role in venous and arterial thrombosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
J EmmerichJ N Fiessinger

Abstract

Activated protein C resistance is the most prevalent cause of thrombophilia: it is found in 20 to 30% of patients with a deep venous thrombosis history. Activated protein C resistance is due to an arginine 506 to glutamine mutation in factor V. This mutation prevents normal inactivation of activated factor V by activated protein C. The estimated increase in relative risk of venous thrombosis is 5- to 10-fold in heterozygotes, and 50- to 100-fold in homozygotes. Activated protein C resistance does not seem to play a role in arterial thrombosis and in the occurrence of myocardial infarction.

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Citations

Dec 16, 1998·Journal of the American Geriatrics Society·E AndréP Gaussem

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