Resistance to antimicrobial peptides in Gram-negative bacteria

FEMS Microbiology Letters
Samantha Gruenheid, Hervé Le Moual

Abstract

Antimicrobial peptides (AMPs) are present in virtually all organisms and are an ancient and critical component of innate immunity. In mammals, AMPs are present in phagocytic cells, on body surfaces such as skin and mucosa, and in secretions and body fluids such as sweat, saliva, urine, and breast milk, consistent with their role as part of the first line of defense against a wide range of pathogenic microorganisms including bacteria, viruses, and fungi. AMPs are microbicidal and have also been shown to act as immunomodulators with chemoattractant and signaling activities. During the co-evolution of hosts and bacterial pathogens, bacteria have developed the ability to sense and initiate an adaptive response to AMPs to resist their bactericidal activity. Here, we review the various mechanisms used by Gram-negative bacteria to sense and resist AMP-mediated killing. These mechanisms play an important role in bacterial resistance to host-derived AMPs that are encountered during the course of infection. Bacterial resistance to AMPs should also be taken into consideration in the development and use of AMPs as anti-infective agents, for which there is currently a great deal of academic and commercial interest.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E A GroismanF Heffron
Sep 1, 1992·Infection and Immunity·P B EisenhauerR I Lehrer
Aug 1, 1992·The Journal of Clinical Investigation·R P DarveauG Maloney
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·W M ShaferR I Lehrer
Feb 13, 2001·Microbiology·I Sutherland
Oct 9, 2002·Molecular Microbiology·Artur SchmidtchenLars Björck
Feb 22, 2003·Infection and Immunity·Nita H SalzmanYvonne Paterson
Aug 14, 2003·Trends in Microbiology·Jetta J E Bijlsma, Eduardo A Groisman
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Carrie M RosenbergerB Brett Finlay
Aug 21, 2004·The Journal of Biological Chemistry·Wenyi JiaRussell E Bishop
Nov 24, 2004·Infection and Immunity·Miguel A CamposJosé A Bengoechea
Dec 21, 2004·Nature Reviews. Microbiology·Samuel I MillerMartin W Bader
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsutoshi IimuraMartin F Kagnoff
Jun 15, 2005·Cellular Microbiology·Peter BergmanBirgitta Agerberth
Jul 21, 2005·Journal of Bacteriology·Yih-Ling TzengDavid S Stephens
Aug 13, 2005·Cell·Martin W BaderSamuel I Miller
Aug 23, 2005·Infection and Immunity·Michael P ShermanCharles L Bevins
Jun 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rubhana RaqibBirgitta Agerberth
Jun 28, 2006·Nutrition and Cancer·Liisa J NohynekRiitta H Puupponen-Pimiä
Dec 13, 2006·Nature Biotechnology·Robert E W Hancock, Hans-Georg Sahl
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyuan WangChristian R H Raetz
May 2, 2007·Infection and Immunity·Maria Rita SpinosaCecilia Bucci
Aug 22, 2007·Molecular Membrane Biology·Victoria Hritonenko, Christos Stathopoulos
Sep 18, 2007·Journal of Bacteriology·Maria NovikovaKonstantin Severinov
Jun 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Amy L DavidsonJue Chen

❮ Previous
Next ❯

Citations

Nov 15, 2012·Journal of Medicinal Chemistry·Mathieu LaurencinMichèle Baudy-Floc'h
Sep 17, 2013·EMBO Molecular Medicine·Maureen J OstaffJan Wehkamp
Feb 2, 2016·Pathogens·Petra Lüthje, Annelie Brauner
Jul 18, 2015·Pharmaceuticals·Biljana Mojsoska, Håvard Jenssen
Nov 13, 2013·Expert Opinion on Investigational Drugs·Ze-Qi XuJohn Flavin
Sep 18, 2014·BMC Plant Biology·Araceli GarcíaGabriela Soto
Sep 19, 2012·Veterinary Microbiology·Anthony W Confer, Sahlu Ayalew
Sep 17, 2013·Angewandte Chemie·Kieron M G O'ConnellDavid R Spring
May 24, 2015·Biochimica Et Biophysica Acta·Yih-Ling Tzeng, David S Stephens
Jul 24, 2015·Biomolecular Concepts·Małgorzata Cytryńska, Agnieszka Zdybicka-Barabas
Jul 2, 2014·Developmental and Comparative Immunology·Larry J DishawWilliam Parker
Jan 15, 2015·Biochimica Et Biophysica Acta·Jianguo LiRoger W Beuerman
Jan 30, 2015·Canadian Journal of Microbiology·Chandra Datta SumiYoung Tae Hahm
May 29, 2013·FEMS Microbiology Letters·John R BrannonHervé Le Moual
Aug 2, 2016·Dental Materials Journal·Jasmin GrischkeMeike Stiesch
Jul 3, 2013·ACS Synthetic Biology·Katherine VolzingYiannis N Kaznessis
Jan 24, 2014·Journal of Agricultural and Food Chemistry·Melanie DerdeFrançoise Nau
Oct 9, 2013·Biomacromolecules·Katherine E S LocockMatthias Haeussler
Apr 4, 2017·Expert Opinion on Biological Therapy·Josep M SierraMiguel Viñas
Aug 5, 2017·Materials·Madson R E SantosJorge F J Coelho
Aug 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MolchanovaHenrik Franzyk
Jul 17, 2013·Antimicrobial Agents and Chemotherapy·Tahsina ShireenKasturi Mukhopadhyay
Sep 10, 2015·Journal of Bacteriology·John R BrannonHervé Le Moual
Jul 6, 2014·The Journal of Biological Chemistry·Ulrich ZähringerGuy R Cornelis
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Damian NeubauerWojciech Kamysz
Aug 2, 2020·World Journal of Microbiology & Biotechnology·Songhita MukhopadhyayUsha Y Nayak
Sep 18, 2020·Pharmaceutics·Miguel Ángel OrtegaSandra García-Gallego
Apr 30, 2017·Chemical Science·Alice PyneMaxim G Ryadnov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.