Abstract
Benign prostatic hyperplasia (BPH) is related to advancing age and the presence of androgens and occurs in virtually all older men. BPH causes morbidity, most often by urinary obstruction, in a substantial fraction of men over sixty. Both finasteride and androgen ablation induce partial diminution in BPH that occurs over weeks to months. This is in contrast to the often rapid involution seen in both normal prostatic epithelium and prostatic carcinoma in response to androgen withdrawal. This study was performed to analyze the response of prostatic cells, and in particular BPH, to acute androgen ablation. We subjected a cohort of 26 men to androgen ablation with goserelin, a gonadotrophin releasing hormone agonist, for 3-4 weeks prior to radical prostatectomy for prostate cancer. Preablation biopsy specimens and prostatectomy specimens were immunohistochemically stained for apoptotic cells and for expression of apoptosis regulatory proteins Bcl-2, Bax, Bcl-x, and Bak. Normal prostatic epithelial cells and prostate cancer responded to hormone deprivation by undergoing apoptosis, but in 19/26 specimens prostatic hyperplasia had a total absence of apoptosis. In all 26 specimens, benign prostatic hyperplasia demonstrated increased ex...Continue Reading
References
Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Dec 1, 1990·The Journal of Urology·H LeporH Sunshine
Nov 1, 1990·British Journal of Urology·D R JonesW B Peeling
Feb 1, 1991·The Journal of Urology·A W PartinP C Walsh
Jul 1, 1989·The Journal of Urology·M YokoyamaM Takeuchi
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J L GabriloveM Droller
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Feb 1, 1989·The Journal of Urology·H L HoltgreweC Proctor
Feb 1, 1988·Endocrinology·N Kyprianou, J T Isaacs
Oct 31, 1974·The New England Journal of Medicine·P C WalshJ D Wilson
Dec 27, 1974·Science·J Imperato-McGinleyR E Peterson
Sep 1, 1984·The Journal of Urology·S J BerryL L Ewing
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Mar 1, 1995·British Journal of Urology·M Caine
Sep 1, 1995·Urology·J L BoschF H Schröder
Jul 1, 1993·The Journal of Urology·L M Eri, K J Tveter
Aug 1, 1993·The Journal of Urology·L M Eri, K J Tveter
Apr 20, 1995·Nature·T ChittendenB C Guild
Apr 20, 1995·Nature·M C KieferP J Barr
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·T SatoH G Wang
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Aug 27, 1993·Cell·L H BoiseC B Thompson
Aug 27, 1993·Cell·Z N OltvaiS J Korsmeyer
May 1, 1996·British Journal of Urology·J TaniguchiK Kawabe
Sep 1, 1953·The Journal of Urology·W W SCOTT
Jul 11, 2008·Journal of Endourology·Riccardo BartolettiNovello Pinzi
Citations
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·M FiorentinoW F Grigioni
Nov 14, 2000·The Prostate·F VacherotD K Chopin
Sep 24, 2005·BioFactors·Eun-Sun Hwang, Phyllis E Bowen
Sep 28, 2004·World Journal of Urology·Wolfgang GlienkeDietger Jonas
Mar 6, 2009·Acta Pharmacologica Sinica·Mayumi SuzukiShizuo Yamada
Oct 17, 1998·British Journal of Urology·M ColombelD Chopin
Dec 23, 2009·PloS One·Harold D LoveSimon W Hayward
Aug 15, 2001·BJU International·M C MichelM Goepel
Jan 5, 2000·BJU International·S J Foley, D M Bailey
Oct 10, 2006·Clinical Genitourinary Cancer·Krisha J OpfermannJeffrey D Forman
Nov 16, 2004·The Journal of Urology·A C Buck
Apr 17, 2002·The Journal of Urology·Robert E GerstenbluthMartin I Resnick
Oct 12, 2005·The Journal of Urology·Shahrokh F ShariatYair Lotan
May 19, 2016·Cancer Investigation·Gayatri SharmaNavneet Agnihotri
Nov 17, 1998·The Journal of Urology·A M De MarzoD S Coffey
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Isha RaniNavneet Agnihotri
Nov 1, 2000·The Prostate. Supplement·T C Thompson, G Yang
Aug 3, 2004·The Prostate·Wanzhong WangJan-Erik Damber
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Stanislav ZelivianskiMing-Fong Lin
Mar 18, 2003·The Prostate·Tobias ZellwegerLukas Bubendorf
Aug 18, 2004·Prostate Cancer and Prostatic Diseases·R Gandour-EdwardsP H Gumerlock
Apr 17, 2002·Endocrinology·Partha P BanerjeeTerry R Brown
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·A De La TailleD Chopin
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·C A RothermundJ K Vishwanatha
Jan 17, 2004·The Journal of Biological Chemistry·Haojie HuangDonald J Tindall
Jan 27, 2018·The Journal of Urology·Steven A Kaplan
Sep 18, 1998·Cancer·C I TruicaK R Meehan
Sep 24, 2004·Journal of Medicinal Food·Eun-Sun Hwang, Phyllis E Bowen
Jun 19, 2015·Experimental Biology and Medicine·Kyung-Sook ChungKwang-Ho Lee
Oct 17, 2019·Nutrients·Young-Jin ChoiEun-Kyung Kim