PMID: 9431510Feb 12, 1998Paper

Resistance to blood flow in nonuniform capillaries

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
T W Secomb, R Hsu

Abstract

Microvessels in living tissues an not uniform cylinders, and red blood cells (RBCs) are continually deformed when traversing them. This may contribute to higher resistance to blood flow observed in microvessels compared with that in corresponding uniform glass tubes. Here, a theoretical model was used to estimate flow resistance in nonuniform capillaries and its dependence on hematocrit, flow rate, and mechanical properties of RBCs. Single-file motion of RBCs through capillaries with sinusoidally varying cross-sections was simulated, assuming axisymmetrical geometry. Effects of cell membrane shear viscosity and elasticity were included. Lubrication theory was used to describe the plasma flow. Predicted resistance to blood flow in capillaries with variable cross-sections was substantially higher than in uniform vessels with the same mean diameters. Resistance depended on vessel geometry, flow rate, and hematocrit. At tube hematocrit 30%, the increase in resistance was 40%-58% when diameter varied between 4.5 and 6 microns with wavelength 20 microns and 58%-77% for variations between 4 and 5 microns with wavelength 10 microns. Larger relative increases in resistance were predicted for RBCs with increased membrane shear viscosity....Continue Reading

Citations

Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Gamal AkabaniMichael R Zalutsky
May 19, 2007·Antioxidants & Redox Signaling·Pedro Cabrales, Marcos Intaglietta
Nov 10, 2001·Annual Review of Biomedical Engineering·G W Schmid-Schönbein
Jun 1, 2013·Comptes rendus. Physique·Timothy W Secomb, Axel R Pries
Dec 24, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gerhard Gompper, Dmitry A Fedosov
Aug 22, 2006·Life Sciences·Esat AdigüzelMelek Bor-Küçükatay
Mar 1, 2015·Microvascular Research·Dinar KatanovDmitry A Fedosov
Jul 9, 2016·Microvascular Research·Jiho YangTae-Rin Lee
Aug 13, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter H ReinhartSergey S Shevkoplyas
Jul 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·A R Pries, T W Secomb
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T W SecombA R Pries

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