Resistance to endocrine therapy of breast cancer: recent advances and tomorrow's challenges

Clinical Breast Cancer
J Geisler, Per Eystein Lønning

Abstract

The role of endocrine therapy in early as well as advanced breast cancer cannot be overrated. Long-term tamoxifen exposure (5 years) in the adjuvant setting has been shown to be effective not only in improving relapse-free and overall survival but also in reducing the incidence of contralateral cancers. Promising results have been achieved in breast cancer prevention with use of antiestrogens. Novel aromatase inhibitors and inactivators have been found superior to conventional treatment in metastatic disease and are currently being evaluated in the adjuvant setting to improve relapse-free and overall survival. If potential health hazards from estrogen deprivation with regard to cardiovascular disease as well as bone metabolism can be addressed, adjuvant endocrine therapy may include such drugs in the future. However, while endocrine therapy of breast cancer has become more and more important in the clinic, the major problems in hormonal therapy are primary and acquired resistance to endocrine manipulations. The causes for endocrine resistance and possible ways to delay or avoid this phenomenon are only allusively understood. Elucidation of the mechanisms underlying endocrine resistance in vivo represents the key to improve our ...Continue Reading

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Citations

Jan 20, 2010·Breast Cancer Research : BCR·Per Eystein Lønning
Jan 27, 2012·Breast Cancer Research : BCR·William R Miller, Alexey A Larionov
May 26, 2010·Expert Opinion on Pharmacotherapy·William R Miller
Jul 19, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Vessela Nedelcheva KristensenAnne-Lise Børresen-Dale
Jun 1, 2002·Drugs & Aging·Per E Lønning
May 1, 2011·Expert Review of Endocrinology & Metabolism·William R Miller
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Virgil T GaddyPatricia V Schoenlein
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jürgen Geisler, Per Eystein Lønning
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·W R Miller

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