Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

Immunity
A HaziotS M Goyert

Abstract

Endotoxin shock is the result of activation of the immune system by endotoxin/LPS, a component of Gram-negative bacteria. CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/LPS. The role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells. CD14-deficient mice were found to be highly resistant to shock induced by either live Gram-negative bacteria or LPS; however, at very high concentrations of LPS or bacteria, responses through non-CD14 receptors could be detected. Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Dec 1, 1992·The Journal of Experimental Medicine·E A FreyS D Wright
Sep 15, 1991·Annals of Internal Medicine·R C Bone
May 1, 1994·The Journal of Experimental Medicine·K MatsuuraS Yamamoto
Apr 1, 1995·The Journal of Experimental Medicine·R R Ingalls, D T Golenbock
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FerreroS M Goyert
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PuginP S Tobias
Apr 1, 1993·Immunobiology·C Galanos, M A Freudenberg

❮ Previous
Next ❯

Citations

Sep 18, 2001·Current Infectious Disease Reports·Bruce Beutler, Richard J. Ulevitch
Mar 12, 2009·Molecules and Cells·Chunghyun LeeSang-Gi Paik
Jul 5, 2006·Heart Failure Reviews·Maria Isabel Tejero-TaldoWilliam Bernard Weglicki
Apr 6, 2004·Advanced Drug Delivery Reviews·V K ViswanathanGail Hecht
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Olivier MichelRagnar Rylander
Jan 31, 2004·Seminars in Immunology·Kensuke Miyake
Mar 31, 2004·Trends in Microbiology·Kensuke Miyake
Jun 27, 2002·Biochemical and Biophysical Research Communications·Douglas D BannermanJohn M Harlan
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Didier Heumann, Thierry Roger
Dec 10, 1999·The Urologic Clinics of North America·V Lazaron, R A Barke
Sep 21, 2000·Immunopharmacology·Y J JeonH M Kim
Jul 1, 1997·Immunology Today·J C Gutierrez-Ramos, H Bluethmann
Sep 27, 2002·Toxicology·Susana Cadenas, Ana M Cadenas
May 26, 1999·Infectious Disease Clinics of North America·R R IngallsD Golenbock
Feb 19, 2000·Current Opinion in Immunology·B Beutler
Feb 19, 2000·Current Opinion in Immunology·C D Gregory
Oct 18, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ozlem KeskinOmer Kalayci
Apr 3, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Suwannee UthaisangsookSoichi Haraguchi
Apr 12, 2000·Microbes and Infection·R LandmannW Zimmerli
Jul 11, 2002·Microbes and Infection·Marina A Dobrovolskaia, Stefanie N Vogel
Jul 10, 1999·The International Journal of Biochemistry & Cell Biology·C Schütt
May 19, 2000·Cytokine & Growth Factor Reviews·T K MeansM J Fenton
Aug 28, 2003·Current Opinion in Chemical Biology·Jeffrey A Lawton, Partho Ghosh
Mar 6, 1999·Current Opinion in Microbiology·D HeumannT Calandra
Jan 18, 2003·Biochimica Et Biophysica Acta·Yannick HamonGiovanna Chimini
May 19, 2001·International Immunopharmacology·O Takeuchi, S Akira
Dec 7, 2013·Experimental & Molecular Medicine·Beom Seok Park, Jie-Oh Lee
Jun 3, 2004·Nature Reviews. Immunology·Seung-Yong Seong, Polly Matzinger
Feb 4, 2012·Nature Reviews. Immunology·Clarissa C LeeHidde L Ploegh
Dec 1, 2009·Nature Reviews. Microbiology·Clare E BryantNicholas J Gay
Jul 4, 2007·Immunology and Cell Biology·Trevor HuytonMatthew Wilce
May 6, 1998·European Journal of Clinical Investigation·F StelterC Schütt
Jan 29, 2000·European Journal of Clinical Investigation·P Antal-Szalmás
Sep 14, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Takeda, S Akira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E FerreroS M Goyert
Proceedings of the National Academy of Sciences of the United States of America
J SchimkeR J Ulevitch
The Journal of Clinical Investigation
D LeturcqR J Ulevitch
© 2021 Meta ULC. All rights reserved