Resistance to fluoroquinolones by the combination of target site mutations and enhanced expression of genes for efflux pumps in Shigella flexneri and Shigella sonnei strains isolated in Korea

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
J-Y KimB-K Lee

Abstract

Among 5938 clinical Shigella spp. isolates, two S. flexneri strains were isolated as those resistant to fluoroquinolones based on the MICs of the following antibiotics: ciprofloxacin, norfloxacin, ofloxacin, sparfloxacin and levofloxacin. S. flexneri 021787 had three substitutions, one in GyrA (Ser83Leu) and two in ParC (Ser80Ile and Arg91Gln). S. flexneri 021895 had four substitutions, two in GyrA (Ser83Leu and Asp87Gly) and two in ParC (Ser80Ile and Arg91Gln). The increased susceptibility of S. flexneri 021787 and S. flexneri 021895 to ciprofloxacin, norfloxacin and ofloxacin in the presence of the uncoupler carbonyl cyamide-m-chlorophenyldrazone implied that energy-dependent active efflux pumps contributed to the resistance against fluoroquinolones. Both S. flexneri 021787 and S. flexneri 021895 were also induced to express tolC (encoding a resistance-nodulation-division transporter), mdfA (encoding a major facilitator superfamily transporter), and ydhE (encoding a multidrug and toxic compound extrusion transporter) in the presence of ciprofloxacin. Thus, these results indicated that chromosome-mediated fluoroquinolone resistance of S. flexneri 021787 and S. flexneri 021895 resulted from the combination of target site mutati...Continue Reading

References

Jun 1, 1990·Antimicrobial Agents and Chemotherapy·H YoshidaS Nakamura
Jan 1, 1988·Molecular & General Genetics : MGG·H YoshidaS Nakamura
Dec 1, 1994·Trends in Microbiology·D MaH Nikaido
Feb 1, 1996·Antimicrobial Agents and Chemotherapy·J VilaM T De Anta
Jan 1, 1997·Antimicrobial Agents and Chemotherapy·Q C TruongN J Moreau
Dec 1, 1996·Microbiological Reviews·I T PaulsenR A Skurray
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·S S PaoM H Saier
Sep 28, 1999·Trends in Microbiology·M N Alekshun, S B Levy
Nov 30, 1999·Antimicrobial Agents and Chemotherapy·J AhamedA K Sinha
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·K Poole
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·A GiuliettiC Mathieu
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Rodrigo AlonsoPatrice Courvalin
Jan 14, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Sylvie BaucheronAxel Cloeckaert
Sep 3, 2003·The Journal of Antimicrobial Chemotherapy·Vito Ricci, Laura Piddock
Jan 7, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K Poole
Nov 6, 2004·Journal of Clinical Microbiology·Seonghan KimBokkwon Lee
Sep 30, 2006·The Lancet Infectious Diseases·Ari RobicsekDavid C Hooper

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Citations

Sep 28, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yihai GuShenghui Cui
Jul 17, 2014·PloS One·Ishrat J AzmiKaisar A Talukder
Jul 21, 2016·Journal of Global Antimicrobial Resistance·Reza RanjbarCaterina Mammina
Jan 4, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi YamaneMasayuki Nakagawa
Jun 29, 2011·FEMS Microbiology Reviews·Hiroshi Nikaido, Jean-Marie Pagès
Feb 15, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S QiuH Song
Apr 11, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Bing GuPing Ma
Aug 31, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Zhen ZhuJiyu Zhang
Sep 6, 2012·Annals of Laboratory Medicine·You La JeonHee Joo Lee
Dec 1, 2011·Osong Public Health and Research Perspectives·Jun-Young KimSeong-Han Kim
Jan 1, 2013·International Journal of Bacteriology·Sanath KumarManuel F Varela
Mar 24, 2020·Disease-a-month : DM·Manar Ali AbushaheenPoojdev Jhugroo
Mar 25, 2021·Biomédica : revista del Instituto Nacional de Salud·Edna Catering RodríguezFrancia Patricia Correa

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