Resistance to gray leaf spot of maize: genetic architecture and mechanisms elucidated through nested association mapping and near-isogenic line analysis

PLoS Genetics
Jacqueline BensonRebecca J Nelson

Abstract

Gray leaf spot (GLS), caused by Cercospora zeae-maydis and Cercospora zeina, is one of the most important diseases of maize worldwide. The pathogen has a necrotrophic lifestyle and no major genes are known for GLS. Quantitative resistance, although poorly understood, is important for GLS management. We used genetic mapping to refine understanding of the genetic architecture of GLS resistance and to develop hypotheses regarding the mechanisms underlying quantitative disease resistance (QDR) loci. Nested association mapping (NAM) was used to identify 16 quantitative trait loci (QTL) for QDR to GLS, including seven novel QTL, each of which demonstrated allelic series with significant effects above and below the magnitude of the B73 reference allele. Alleles at three QTL, qGLS1.04, qGLS2.09, and qGLS4.05, conferred disease reductions of greater than 10%. Interactions between loci were detected for three pairs of loci, including an interaction between iqGLS4.05 and qGLS7.03. Near-isogenic lines (NILs) were developed to confirm and fine-map three of the 16 QTL, and to develop hypotheses regarding mechanisms of resistance. qGLS1.04 was fine-mapped from an interval of 27.0 Mb to two intervals of 6.5 Mb and 5.2 Mb, consistent with the h...Continue Reading

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Citations

Feb 22, 2016·BMC Genomics·Aurore DesgrouxMarie-Laure Pilet-Nayel
Jun 15, 2016·Annual Review of Phytopathology·Tyr Wiesner-Hanks, Rebecca Nelson
Mar 16, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xinye ZhangPeter Balint-Kurti
Mar 28, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xinye ZhangPeter Balint-Kurti
Feb 17, 2017·Journal of Integrative Plant Biology·Kristen A LeachDavid M Braun
Jun 29, 2018·PloS One·Maurício Carlos KukiRonald José Barth Pinto
May 30, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Lei DuKede Liu
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Nov 8, 2017·Nature Reviews. Genetics·Rebecca NelsonPeter Balint-Kurti
Jun 18, 2019·Annual Review of Phytopathology·Christina Cowger, James K M Brown
Apr 30, 2020·The Plant Journal : for Cell and Molecular Biology·Laura MoralesPeter J Balint-Kurti
Oct 22, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Emma MaceDavid Jordan
Nov 20, 2016·The Plant Journal : for Cell and Molecular Biology·Nanette ChristieDave K Berger
Oct 5, 2021·Frontiers in Plant Science·Hongbo QiuGuangxiao Bai

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Methods Mentioned

BETA
PCR

Software Mentioned

SAS
BLAST
ASReml3
AmiGO

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