PMID: 2107540Mar 1, 1990Paper

Resistance to juvenile hormone and an insect growth regulator in Drosophila is associated with an altered cytosolic juvenile hormone-binding protein

Proceedings of the National Academy of Sciences of the United States of America
L Shemshedini, T G Wilson

Abstract

The Met mutant of Drosophila melanogaster is highly resistant to juvenile hormone III (JH III) or its chemical analog, methoprene, an insect growth regulator. Five major mechanisms of insecticide resistance were examined in Met and susceptible Met+ flies. These two strains showed only minor differences when penetration, excretion, tissue sequestration, or metabolism of [3H]JH III was measured. In contrast, when we examined JH III binding by a cytosolic binding protein from a JH target tissue, Met strains had a 10-fold lower binding affinity than did Met+ strains. Studies using deficiency-bearing chromosomes provide strong evidence that the Met locus controls the binding protein characteristics and may encode the protein. These studies indicate that resistance in Met flies results from reduced binding affinity of a cytosolic binding protein for JH III.

References

Feb 1, 1978·The Journal of Experimental Zoology·J H Postlethwait, G J Jones
Jan 1, 1975·Annual Review of Entomology·G B Staal
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S RichardL I Gilbert
Nov 1, 1986·Developmental Biology·T G Wilson, J Fabian
Jul 1, 1967·Scientific American·C M Williams
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Aug 1, 1983·Computer Programs in Biomedicine·G A McPherson
Sep 1, 1982·The Quarterly Review of Biology·M Bownes
Nov 1, 1982·Developmental Biology·B Stevens, J D O'Connor
Jul 1, 1983·Molecular and Cellular Endocrinology·P E Roberts, G R Wyatt
Dec 1, 1981·Endocrinology·J A Cidlowski, N B Cidlowski
Mar 1, 1965·The Journal of Experimental Zoology·F M BUTTERWORTHR C KING

❮ Previous
Next ❯

Citations

May 1, 1997·The Journal of Experimental Zoology·T G Wilson, J R Cryan
Jan 1, 1996·Archives of Insect Biochemistry and Physiology·T G Wilson
Feb 18, 1998·Archives of Insect Biochemistry and Physiology·L ZhangT Shono
Jan 1, 1993·Archives of Insect Biochemistry and Physiology·D Segal
Jan 1, 1995·Archives of Insect Biochemistry and Physiology·C Turner, T G Wilson
Jan 1, 1992·Parasitology Research·M Spindler-Barth
Jun 28, 2006·Molecular Genetics and Genomics : MGG·Thomas G WilsonRobert Farkas
Sep 1, 1995·Insect Biochemistry and Molecular Biology·V C Henrich, N E Brown
Mar 24, 2004·Trends in Genetics : TIG·Richard H Ffrench-ConstantGaelle Le Goff
May 29, 2003·Journal of Insect Physiology·L I. GilbertD S. Richard
May 29, 2003·Journal of Insect Physiology·N E. GruntenkoI Y. Rauschenbach
Jun 22, 1999·Molecular and Cellular Endocrinology·A P OrthW G Goodman
Jul 6, 2000·Insect Biochemistry and Molecular Biology·N E GruntenkoI Y Rauschenbach
Jun 11, 2010·Proceedings. Biological Sciences·Elizabeth A Tibbetts, Maral Banan
Dec 1, 2001·Annual Review of Entomology·James W Truman, Lynn M Riddiford
Aug 12, 2008·The Journal of Experimental Biology·Thomas FlattNeal Silverman
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M AshokT G Wilson
Jun 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Barbora Konopova, Marek Jindra
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Judith H Willis
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·T G Wilson, M Ashok
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tugrul GirayMary Jane West-Eberhard
Sep 22, 2012·Annual Review of Entomology·Marek JindraLynn M Riddiford
Sep 14, 2010·Biochemical and Biophysical Research Communications·Haiying ZhangYong Q Zhang
Feb 22, 2012·Hormones and Behavior·Elizabeth A Tibbetts, Michael J Sheehan
Oct 5, 2011·Insect Biochemistry and Molecular Biology·Mohamed A AbdouJian Wang
Mar 22, 2008·Journal of Insect Physiology·Lynn M Riddiford
Mar 7, 2006·Biochemical and Biophysical Research Communications·Jakub GodlewskiThomas G Wilson
Aug 6, 2000·Developmental Biology·E B DubrovskyE M Berger
Mar 24, 2011·Insect Biochemistry and Molecular Biology·Trent PerryPhillip J Daborn
May 7, 2011·Journal of Insect Physiology·Elizabeth A TibbettsKellie Donajkowski
Jan 10, 2006·Vitamins and Hormones·Edward M Berger, Edward B Dubrovsky
Aug 24, 2002·Pest Management Science·Anthony J CornelF Steve Mulligan
Mar 17, 2001·Nature Reviews. Genetics·D Schneider
Jul 5, 2018·Biological Reviews of the Cambridge Philosophical Society·Nichola J HawkinsPaul Neve

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.