Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones

International Journal of Medical Microbiology : IJMM
Immaculada Quiles-MeleroJesús Mingorance

Abstract

A linezolid-resistant, methicillin-susceptible isolate of Staphylococcus aureus was obtained from an infected surgical wound in an ambulatory patient. The isolate belonged to ST125 and was susceptible to all the antibiotics tested except linezolid (MIC 8 μg/ml) and levofloxacin. Linezolid resistance could be ascribed to the presence of the mutation G2576T in 2 of the 23S rRNA alleles. The mutant alleles were stably maintained in the absence of antibiotic selection.

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Citations

Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P Lodise, G L Drusano
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey B LockeKenneth Bartizal
Dec 28, 2012·Journal of Clinical Microbiology·Inmaculada Quiles-MeleroJesús Mingorance
Oct 1, 2014·Pharmacotherapy·Jeffrey M RybakCraig A Martin
May 31, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Diane Cappelletty, David Jacobs

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