Abstract
Mouse strains differ markedly in resistance to Mycoplasma pulmonis infection, and investigation of these differences holds much promise for understanding the mechanisms of antimycoplasmal host defenses. To determine the potential genetic diversity of resistance to disease in murine respiratory mycoplasmosis (MRM) and to select disease-resistant and nonresistant mouse strains for further genetic analysis, we screened 17 inbred mouse strains of various Bcg and H-2 genotypes for resistance to M. pulmonis. Mice were inoculated intranasally with 10(4) CFU of M. pulmonis UAB CT and evaluated at 21 days postinfection for severities of the four histologic lung lesions characteristic of MRM: alveolar exudate, airway exudate, airway epithelial hyperplasia, and lymphoid infiltrate. On the basis of these assessments of MRM severity, one group of mouse strains was found to be extremely resistant to disease (C57BR/cdJ, C57BL/6NCr, C57BL/10ScNCr, and C57BL/6J). The remaining strains of mice (C57L/J, SJL/NCr, BALB/cAnNCr, A/JCr, C3H/HeJ, SWR/J, AKR/NCr, CBA/NCr, C58/J, DBA/2NCr, C3H/HeNCr, C3HeB/FeJ, and C3H/HeJCr) developed disease of widely varying severities. Furthermore, strains in the group with more disease varied in pattern of lesion se...Continue Reading
References
Jun 1, 1979·The Journal of Infectious Diseases·H M FoyI D Allan
Feb 1, 1992·The American Review of Respiratory Disease·J K DavisJ R Lindsey
Aug 1, 1991·Current Opinion in Immunology·E Skamene, C E Pietrangeli
Oct 25, 1991·Science·W R Atchley, W M Fitch
Jun 1, 1990·The Journal of Infectious Diseases·W C LaiA Mikhael
Aug 1, 1989·The American Review of Respiratory Disease·R F ParkerJ W Simecka
Aug 1, 1988·Infection and Immunity·M K DavidsonG H Cassell
Nov 1, 1987·Infection and Immunity·R F ParkerG H Cassell
Sep 1, 1986·Veterinary Pathology·D M PinsonJ K Davis
Apr 1, 1986·The American Journal of Medicine·C M RoifmanE W Gelfand
Dec 1, 1985·Infection and Immunity·J K DavisG H Cassell
Aug 1, 1972·Journal of Medical Microbiology·F W DennyA C Allison
Jan 1, 1971·The Journal of Infectious Diseases·F W DennyW P Glezen
May 1, 1982·Veterinary Pathology·J K Davis, G H Cassell
May 1, 1982·Reviews of Infectious Diseases·G H Cassell
Aug 1, 1980·Infection and Immunity·J K DavisG H Cassell
Oct 1, 1995·Infection and Immunity·C B FaulknerM P Everson
Oct 1, 1995·Infection and Immunity·S C CartnerJ K Davis
Oct 1, 1994·Immunobiology·E Skamene
Dec 1, 1994·Clinical and Experimental Immunology·B EvengårdC I Smith
Sep 30, 1994·Science·E S Lander, N J Schork
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M Foy
Nov 1, 1993·Infection and Immunity·W C LaiS P Pakes
May 7, 1993·Cell·S M VidalP Gros
Citations
Sep 13, 2001·Infection and Immunity·J M Hickman-DavisS Matalon
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong Wei ChuRichard J Martin
May 12, 2009·Ecological Applications : a Publication of the Ecological Society of America·Arpat OzgulCarolina Perez-Heydrich
Sep 26, 2013·The Journal of Veterinary Medical Science·Atsushi AsanoTakashi Agui
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·J Hickman-DavisS Matalon
Jan 1, 2005·American Journal of Respiratory Cell and Molecular Biology·Monica Fonseca-AtenR Doug Hardy
Sep 10, 2003·American Journal of Respiratory Cell and Molecular Biology·Judy M Hickman-DavisSadis Matalon
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandra Shekhar BakshiTimothy J Sellati
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Judy M Hickman-DavisSadis Matalon
Sep 23, 2003·Infection and Immunity·Warren L Simmons, Kevin Dybvig
Apr 5, 2002·European Journal of Immunology·Séverine HavouisChristine Pourcel
Jan 31, 2009·European Journal of Immunology·Amy N SieveRance E Berg
May 4, 2011·Respiratory Research·Rudi AlbertsKlaus Schughart
Feb 8, 2013·PloS One·Xiangle SunJerry W Simecka
May 14, 2016·PloS One·Adam N Odeh, Jerry W Simecka
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arin B AuroraNigel Killeen
Sep 22, 2006·Infection and Immunity·Xiangle SunJerry W Simecka
Jul 23, 1998·Infection and Immunity·S C CartnerJ W Simecka
Mar 9, 2021·Frontiers in Veterinary Science·Manoel Neres Santos JuniorLucas Miranda Marques
Mar 5, 1998·The American Journal of Physiology·J M Hickman-DavisS Matalon
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·J M Hickman-Davis
Dec 22, 2017·Infection and Immunity·Nadeeka K WawegamaThomas C Brodnicki
Jul 11, 2018·Infection and Immunity·Maximillion T MizeJerry W Simecka
Dec 22, 1999·Trends in Microbiology·I ChambaudA Blanchard
May 1, 2021·Immunology·Ying LuoAihua Lei
Jun 20, 1998·Clinical Microbiology Reviews·D G Baker
Oct 8, 1997·Infection and Immunity·C BrennerA Blanchard