Resistance to re-challenge in the Brown Norway rat model of vasculitis is not always complete and may reveal separate effector and regulatory populations

Immunology
C S VinenDavid Oliveira

Abstract

Administration of mercuric chloride to Brown Norway rats results in T helper type 2 (Th2)- dominated autoimmunity characterized by high immunoglobulin E (IgE) concentrations, the production of multiple IgG autoantibodies, including those to glomerular basement membrane (GBM), arthritis and caecal vasculitis. After 14 days animals immunoregulate and auto-immunity resolves even if mercuric chloride injections are continued. In a third phase, if animals are re-challenged with mercuric chloride 6 weeks later, they show only attenuated autoimmunity with lower anti-GBM antibody concentrations and arthritis scores. Resistance to the induction of anti-GBM antibodies can also be achieved following an initial challenge with low-dose (one-tenth standard dose) mercuric chloride. We have now studied this resistant phase in more detail. We have shown, first, that following an initial full-dose mercuric chloride challenge, resistance also affects susceptibility to caecal vasculitis. Second, following an initial full-dose mercuric chloride challenge, the IgE response upon re-challenge is initially accelerated but subsequently enters a resistant phase and third, following an initial challenge with low-dose mercuric chloride, resistance is also ...Continue Reading

References

Jul 1, 1990·Clinical and Experimental Immunology·C D PuseyC M Lockwood
Aug 1, 1987·Kidney International·L PelletierP Druet
Jul 1, 1981·Clinical Immunology and Immunopathology·J F BernaudinR Masse
Nov 1, 1993·The Journal of Experimental Medicine·C G Romball, W O Weigle
Mar 1, 1995·Scandinavian Journal of Immunology·K M GillespieP W Mathieson
Jun 11, 1999·Advances in Immunology·E C ButcherM Briskin
Sep 1, 1999·International Journal of Experimental Pathology·F E HarrisD B Oliveira
Nov 24, 1999·Immunological Reviews·C CzerkinskyJ B Sun
Sep 29, 2000·International Immunology·A C FieldB Bellon

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Citations

Mar 15, 2005·Clinical and Experimental Immunology·C S VinenD B G Oliveira

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