Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies

Pediatrics
Akhil MaheshwariD A Calhoun

Abstract

Neonatal alloimmune neutropenia is the neutrophil counterpart of the erythrocyte disorder of hemolytic disease of the newborn. Fetal neutrophil antigens, which are inherited from the father but foreign to the pregnant mother, provoke the formation of maternal antibodies, which, on transplacental passage, cause fetal/neonatal neutropenia. Because infants with this disorder are at a higher risk of infection, recombinant hematopoietic growth factors, such as recombinant human granulocyte colony-stimulating factor, have been tried, with generally good results, to treat those with severe and prolonged neutropenia. We report a neonate who had neonatal alloimmune neutropenia associated with antibodies directed against human neutrophil antigen-2a (NB1) and initially failed to respond to even very high doses of recombinant human granulocyte colony-stimulating factor but eventually had a therapeutic response.

References

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Citations

Dec 11, 2013·Current Opinion in Hematology·Akhil Maheshwari
Sep 22, 2012·Journal of Pediatric Hematology/oncology·Sofia ÁguedaHercília Guimarães
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Solomon NittalaAkhil Maheshwari
Jan 27, 2009·Seminars in Perinatology·L Vandy Black, Akhil Maheshwari
Jan 23, 2008·Vox Sanguinis·J Bux
Nov 20, 2015·World Journal of Pediatrics : WJP·Piero Farruggia
Jun 9, 2004·Clinics in Perinatology·Robert D Christensen, Darlene A Calhoun
Aug 8, 2006·Journal of Korean Medical Science·Tae Hee HanKyou Sup Han
Dec 13, 2002·Acta Paediatrica. Supplement·A MaheshwariD A Calhoun
May 3, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Leendert Porcelijn, Masja de Haas

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