PMID: 11911676Mar 26, 2002Paper

Resistance to serum killing may contribute to differences in the abilities of capsulate and non-capsulated isolates of lactococcus garvieae to cause disease in rainbow trout (Oncorhynchus mykiss L.)

Fish & Shellfish Immunology
Andrew C BarnesAnthony E Ellis

Abstract

Three capsulated and two non-capsulated isolates of Lactococcus garvieae were investigated in terms of their wall proteins, virulence and interactions with rainbow trout immunoglobulin (Ig). All isolates were similar in integral membrane protein profile, and all were able to bind non-immune rainbow trout Ig, although different proteins appeared to be involved in Ig binding. However, whilst capsulated isolates were highly virulent, non-capsulated isolates were avirulent. This appeared to correlate with susceptibility of the non-capsulated isolates to rainbow trout normal serum. In contrast, the capsulated isolates were resistant to both normal and immune serum killing. In spite of this, passive immunisation of rainbow trout with specific anti-serum to L. garvieae was able to protect against challenge by capsulated isolates of L. garvieae. This suggests the antibody may have some other role in protection against disease caused by this important Gram-positive bacterial fish pathogen.

Citations

Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Chin-I ChangChristopher J Secombes
Sep 4, 2004·Applied and Environmental Microbiology·Marina EyngorAvi Eldar
Feb 18, 2010·Infection and Immunity·Esteban SotoJohn P Hawke
Jul 26, 2005·Infection and Immunity·Chin-I ChangChristopher J Secombes
Jun 9, 2009·Journal of Fish Diseases·M AlgöetD W Verner-Jeffreys
Oct 24, 2009·Journal of Applied Microbiology·M Y JungW Kim
May 5, 2004·Fish & Shellfish Immunology·Andrew C Barnes, Anthony E Ellis
Feb 9, 2017·Diseases of Aquatic Organisms·C M MeyburghC E Boucher
Mar 7, 2014·Current Microbiology·Richard William McLaughlinScot E Dowd
Oct 2, 2007·Microbiology·Aurora MenéndezJosé A Guijarro

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