Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them

Journal of General Microbiology
R H Skinner, E Cundliffe

Abstract

Viomycin capreomycin, antibiotics produced by Streptomyces vinaceus and S. capreolus respectively, are potent inhibitors of bacterial protein synthesis. Although these organisms are highly tolerant of their own products in vivo, their ribosomes are fully sensitive to the action of the drugs in vitro. However, they processes novel, antibiotic-inactivating enzymes (viomycin phosphotransferase, capreomycin phosphotransferase, capreomycin acetyltransferase) which, in addition to possible biosynthetic roles, may contribute to the resistances observed in vivo.

Citations

May 7, 2010·Journal of Industrial Microbiology & Biotechnology·Eric Cundliffe, Arnold L Demain
Jun 14, 2005·Advanced Drug Delivery Reviews·Gerard D Wright
Dec 13, 2012·The Journal of Antimicrobial Chemotherapy·Jacob L HoughtonSylvie Garneau-Tsodikova
May 15, 2007·Applied and Environmental Microbiology·Elizabeth A FelnagleMichael G Thomas
Jan 1, 1983·Microbiology and Immunology·Y MizuguchiT Yamada

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