Resistance to thyroid hormone: report of 2 kindreds with 35 patients.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
João Anselmo, R César

Abstract

To report two kindreds with resistance to thyroid hormone (RTH), particularly the clinical and laboratory evolution after thyroidectomy and with antithyroid drug treatment. Clinical data and thyroid function were determined in 82 members from three different generations of both families. Unaffected relatives were used as a control group. Response of thyroid-stimulating hormone (TSH) to the hypothalamic thyrotropin-releasing hormone (TRH) was evaluated in five patients and compared with five nonaffected relatives. Thirty-five (22 male and 13 female) patients had high serum levels of thyroxine and triiodothyronine in conjunction with nonsuppressed TSH. Goiter was present in 66% of affected family members; prevalence was 10% in childhood and 88% in adulthood. The prevalence of goiter was 18% in nonaffected relatives. No patient showed evidence of thyroid hypofunction or hyperfunction, and the TSH response to TRH was similar to that of nonaffected relatives. The incidence of RTH in offspring was 60%, consistent with autosomal dominant transmission. Four patients had undergone thyroidectomy, and two required a second operation because of recurrence of goiter. Patients who had undergone thyroidectomy had normal or near-normal levels ...Continue Reading

References

Sep 1, 1977·The Journal of Clinical Endocrinology and Metabolism·I A KouridesF Maloof
Jan 1, 1992·Annual Review of Medicine·R E Weiss, S Refetoff
Sep 14, 1990·Biochemical and Biophysical Research Communications·S J UsalaB D Weintraub
Dec 1, 1990·The Journal of Clinical Investigation·M A Lazar, W W Chin
Jun 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M H SamuelsE C Ridgway
Jan 1, 1987·Annual Review of Physiology·J H Dussault, J Ruel
Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M M Menezes-FerreiraB D Weintraub
Mar 18, 1982·The New England Journal of Medicine·M RuizS H Ingbar
Jul 1, 1980·The Journal of Clinical Endocrinology and Metabolism·S RefetoffC P Barsano
Sep 1, 1981·Annals of Internal Medicine
May 1, 1981·The American Journal of Medicine·M M KaplanP R Larsen
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·J L Jameson
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·S Refetoff
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·P Beck-Peccoz, V K Chatterjee
Apr 8, 1993·The New England Journal of Medicine·P HauserB D Weintraub
Apr 1, 1993·The American Journal of Medicine·M T McDermott, E C Ridgway
Apr 1, 1996·The Journal of Endocrinology·D W Ray

❮ Previous
Next ❯

Citations

Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·Helmut GrasbergerSamuel Refetoff
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Roy E WeissSamuel Refetoff

❮ Previous
Next ❯

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.