Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease

Muscle & Nerve
Robert D ChetlinRachel A Yeater

Abstract

Resistance exercise and creatine supplementation independently improve strength and function in patients with certain neuromuscular diseases. The purpose of this study was to examine the effects of resistance training with and without creatine supplementation on muscle, strength, and function in patients with Charcot-Marie-Tooth (CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or placebo while participating in resistance training for 12 weeks. Energy metabolites, muscle fiber type and size, strength, and timed activities of daily living were measured before and after training. There were no differences between creatine or placebo groups for any outcome. For the groups combined, exercise training increased type I muscle fiber diameter (48.2 +/- 14.2 microm vs. 55.4 +/- 14.8 microm), strength, and activities of daily living (ADL) times. Thus, patients respond to resistance training with muscle fiber adaptations, and improvements in strength and function. Creatine was not beneficial.

References

Sep 1, 1970·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M H Brooke, K K Kaiser
Feb 1, 1983·Acta Physiologica Scandinavica·E NygaardB Saltin
Jun 1, 1995·International Journal of Sport Nutrition·P L Greenhaff
Nov 1, 1993·Archives of Neurology·P F Chance, D Pleasure
Jul 1, 1993·Archives of Physical Medicine and Rehabilitation·S G AitkensE M Bernauer
Feb 11, 1998·Journal of Neurology·M M Reilly
Jul 31, 1998·Trends in Neurosciences·C O Hanemann, H W Müller
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·U EricsonK Borg
Sep 17, 1999·Neurology·S R SchwidA D Goodman
Nov 21, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·M A Tarnopolsky
Mar 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·G PfeifferK Kunze
Jan 22, 2002·Exercise and Sport Sciences Reviews·Kristian Borg, UllaBritt Ericson-Gripenstedt
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·David D Kilmer
Feb 1, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea BroseMark A Tarnopolsky
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·L ERIKSENS HAAVALDSEN

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Citations

Mar 13, 2008·Current Treatment Options in Neurology·Gregory T CarterJohn D England
Jun 23, 2009·Lancet Neurology·Davide Pareyson, Chiara Marchesi
Oct 30, 2007·Archives of Physical Medicine and Rehabilitation·Edith H CupRob A Oostendorp
May 23, 2013·Muscle & Nerve·Yaacov Anziska, Alex Sternberg
Jun 20, 2006·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·L FéassonG-Y Millet
Oct 11, 2005·Physical Medicine and Rehabilitation Clinics of North America·Amy J HoffmanGregory T Carter
Aug 2, 2005·Pharmacology & Therapeutics·Hoon RyuRobert J Ferrante
Apr 11, 2014·Physiotherapy Canada. Physiothérapie Canada·Anuradha SawantTom J Overend
Jan 18, 2014·PM & R : the Journal of Injury, Function, and Rehabilitation·Rima El-AbassiGregory T Carter
Aug 6, 2004·Archives of Physical Medicine and Rehabilitation·Robert D ChetlinRachel A Yeater
Sep 11, 2017·American Journal of Medical Genetics. Part a·James J DowlingCraig Campbell
Oct 21, 2004·The Cochrane Database of Systematic Reviews·C M WhiteL Turner-Stokes
Feb 7, 2008·The Cochrane Database of Systematic Reviews·P YoungT Butterfass-Bahloul
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Rudolf A KleyMatthias Vorgerd
Jun 16, 2006·Neuromolecular Medicine·Michael E Shy
May 27, 2015·Journal of the Peripheral Nervous System : JPNS·Amy D SmanJoshua Burns
Jul 25, 2019·International Journal of Molecular Sciences·Jonathan MorenaJ Chad Hoyle
Jun 3, 2021·Nutrients·Kylie K HarmonMatt S Stock

❮ Previous
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