Resistance Training Increases Muscle Strength and Muscle Size in Patients With Liver Cirrhosis.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Luise AamannNiels Kristian Aagaard

Abstract

Cirrhosis is often complicated by reduced muscle mass and strength, which limits the ability to perform daily activities and affects quality of life. Resistance training can increase muscle strength and mass in elderly and chronically ill patients. We performed a randomized controlled trial to investigate whether resistance training increases muscle strength and size in patients with compensated cirrhosis. We performed a prospective study of 39 patients with cirrhosis (Child-Pugh class A or B) seen at an outpatient clinic in Denmark from January 2015 through March 2017. Participants protein intake and activity levels were registered daily. Participants were randomly assigned (1:1) to a group that performed 36 1-hour sessions of physical exercise (supervised progressive resistance training for 1 hour, 3 times weekly for 12 weeks) or a control group (no change in daily activity level). Maximal muscle strength was measured as the peak torque in isokinetic knee extension and muscle size was measured as the cross-sectional area of the quadriceps muscle, assessed by magnetic resonance imaging of the thigh. The exercise group increased their muscle strength by 13% (from a mean 119 Nm to 134 Nm)-an 11 Nm greater gain in mean strength t...Continue Reading

Citations

Jan 22, 2020·Alimentary Pharmacology & Therapeutics·Andrew M MoonA Sidney Barritt
Jan 23, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Poh Hwa OoiDiana R Mager
Jan 31, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fei-Pi LinAndrés Duarte-Rojo
Apr 9, 2020·Journal of Clinical Medicine·Tatsunori HanaiMasahito Shimizu
Feb 28, 2021·Journal of Gastroenterology and Hepatology·Jack WestMarie Sinclair
Mar 13, 2021·European Journal of Translational Myology·Andrea GonzalezClaudio Cabello-Verrugio
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christian Skou EriksenSøren Møller
Apr 12, 2021·Clinics in Liver Disease·Shira Zelber-SagiLiat Deutsch
May 13, 2021·Clinics in Liver Disease·Yedidya Saiman, Marina Serper
Jul 8, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jennifer C LaiElizabeth J Carey
May 22, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chathur Acharya, Jasmohan S Bajaj
Mar 17, 2021·Transplantation·Isabel Campos-VarelaSalvador Augustin
Nov 26, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sophie L AllenLeigh Breen

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