Resistin in idiopathic inflammatory myopathies.

Arthritis Research & Therapy
Mária FilkováLadislav Senolt

Abstract

The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity. Serum resistin levels were determined in 42 patients with inflammatory myopathies and 27 healthy controls. The association among resistin levels, inflammation, global disease activity and muscle strength was examined. The expression of resistin in muscle tissues from patients with inflammatory myopathies and healthy controls was evaluated. Gene expression and protein release from resistin-stimulated muscle and mononuclear cells were assessed. In patients with inflammatory myopathies, the serum levels of resistin were significantly higher than those observed in controls (8.53 ± 6.84 vs. 4.54 ± 1.08 ng/ml, P < 0.0001) and correlated with C-reactive protein (CRP) levels (r = 0.328, P = 0.044) and myositis disease activity assessment visual analogue scales (MYOACT) (r = 0.382, P = 0.026). Stronger association was observed between the levels of serum resistin and CRP levels (r = 0.717, P = 0.037) as well as MYOACT (r = 0.798, P = 0.007), and there was a trend towards correla...Continue Reading

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Citations

Apr 18, 2013·Current Rheumatology Reports·Mária FilkováJiří Vencovský
Jun 14, 2013·Skeletal Muscle·Sree RayavarapuKanneboyina Nagaraju
Sep 29, 2012·Current Opinion in Rheumatology·Rawad NasrErik J Peterson
Sep 18, 2020·Current Opinion in Rheumatology·Lucie Andrés CerezoLadislav Šenolt
Mar 14, 2017·Journal of Diabetes Research·Mostafa Wanees Ahmed El HussenyMohamed M Abdel-Daim
Sep 26, 2015·Current Rheumatology Reports·Jeannette M OlazagastiAnn M Reed
May 26, 2017·Rheumatology International·Javier Loaiza-FélixM Luis Amezcua-Guerra
Jul 2, 2021·Clinical & Translational Immunology·Abbe N VallejoJerry Vockley

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Methods Mentioned

BETA
biopsy
ELISA
density gradient centrifugation
PCR

Software Mentioned

GraphPad
GraphPad Prism

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