Resistin inhibits neuronal autophagy through Toll-like receptor 4

The Journal of Endocrinology
Jie MiaoMohammed Taouis

Abstract

Autophagy is a non-selective degradation pathway induced in energy-deprived cells and in non-starved cells by participating in cellular inflammatory responses mainly through the elimination of injured and aged mitochondria that constitute an important source of reactive oxygen species. We have previously reported that resistin/TLR4 signaling pathway induces inflammation and insulin resistance in neuronal cell. However, the impact of resistin-induced inflammation on neuronal autophagy is unknown. In the present study, we hypothesized that resistin-induced neuroinflammation could be attributed, at least partially, to the impairment of autophagy pathways in neuronal cells. Our data show that resistin decreases neuronal autophagy as evidenced by the repression of the main autophagy markers in SH-SY5Y human neuroblastoma cell line. Furthermore, the silencing of TLR4 completely abolished these effects. Resistin also inhibits AMPK phosphorylation and increases that of Akt/mTOR contrasting with activated autophagy where AMPK phosphorylation is augmented and mTOR inhibited. In vivo, resistin treatment inhibits the mRNA expression of autophagy markers in the hypothalamus of WT mice but not in Tlr4-/- mice. In addition, resistin strongly ...Continue Reading

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Citations

Mar 3, 2018·Archives of Physiology and Biochemistry·Laleh PezhmanMohammad Reza Alipour
Mar 4, 2020·Nutrients·Marina A Sánchez-SánchezRocío Ivette López-Roa
Mar 3, 2020·Frontiers in Aging Neuroscience·P B Tirupathi PichiahShanmugam Achiraman
Feb 28, 2019·Mediators of Inflammation·Cheng-Wu ZhaoXin Qi
Jul 6, 2021·Frontiers in Immunology·Yanran LiZhicai Zuo

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