Resistin involved in endothelial dysfunction among preclinical Tibetan male young adults

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Bo YangTian-De Li

Abstract

Resistin, an adipocyte-derived hormone, was found to be linked to metabolic syndrome and insulin resistance over the past decade. There is growing evidence that resistin plays a potential role in endothelial dysfunction. To the best of our knowledge, few studies have been concerned with the effect of resistin on endothelial function in a Tibetan population. To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults. All participants recruited were young adults between 30 and 40 years old of male gender in Lhasa city. All subjects were native Tibetan. A total of 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia or coronary artery disease. The subjects were divided into three groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B) and higher FMD (group C). Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP) and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The non-invasive vascular endothelial function was evaluated ...Continue Reading

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Citations

Nov 5, 2013·Clinical Biochemistry·Pilar Codoñer-FranchEulalia Alonso-Iglesias

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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