Reslizumab for pediatric eosinophilic esophagitis

Immunotherapy
Garry M Walsh

Abstract

Pediatric eosinophilic esophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the esophagus. Eosinophils are major proinflammatory cells thought to make a major contribution to allergic diseases that affect the upper and lower airways, skin and GI tract. IL-5 is central to eosinophil maturation and release from the bone marrow, and their subsequent accumulation, activation and persistence in the tissues. Reslizumab (Cinquil, Ception Therapeutics Inc., PA, USA) is a humanized monoclonal antibody with potent IL-5 neutralizing effects that represents a potential treatment for eosinophilic diseases. This article considers the current status of the clinical development of reslizumab for pediatric eosinophilic esophagitis.

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Citations

Nov 10, 2011·Paediatric Drugs·Seema Khan
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N A MolfinoG P Geba
Dec 14, 2017·Clinical Reviews in Allergy & Immunology·Mahsa EskianNima Rezaei

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Methods Mentioned

BETA
biopsies
PCR
transfection
bronchoalveolar lavage

Clinical Trials Mentioned

NCT00538434
NCT00635089

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