Resolution of acenocoumarol-associated calciphylaxis with drug withdrawal

The Australasian Journal of Dermatology
José-Manuel Suárez-PeñarandaMaría-Dolores Sánchez-Aguilar

Abstract

Calciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins-associated calciphylaxis have stressed the relevance of anticoagulant therapy as an important risk factor for the development of this condition. We report five cases of acenocoumarol-associated, biopsy-proven calciphylaxis in women aged between 64 and 92 years. The drug had been prescribed for atrial fibrillation and was taken without interruption from 14 to 224 months. Lesions were present for months in all cases and were resistant to multiple therapeutic options, but they resolved only with simple wound care measures 6-14 months after changing the anticoagulant therapy.

References

Mar 16, 2000·The British Journal of Surgery·Y C ChanG Stansby
Jan 22, 2008·Journal of the American Academy of Dermatology·Roger H Weenig
May 23, 2008·Clinical Journal of the American Society of Nephrology : CJASN·John Danziger
Dec 19, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Chandramouli BanerjeeMichael J Lahey
Oct 18, 2011·Actas dermo-sifiliográficas·A Alvarez-PérezJ Toribio
Dec 21, 2012·Indian Journal of Dermatology, Venereology and Leprology·Yu-Chen HuangChun-Hong Hu
May 12, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sagar U NigwekarRavi I Thadhani
Jun 21, 2016·Journal of Clinical Pharmacy and Therapeutics·L HuilajaR Ikäheimo
Jan 19, 2017·JAMA Dermatology·Wesley Yung-Hsu YuLindy P Fox

❮ Previous
Next ❯

Citations

Jun 15, 2020·Cardiovascular Drugs and Therapy·Pietro ScicchitanoMarco Matteo Ciccone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

International Journal of Nephrology
Nicholas NewDwarakanathan Ranganathan
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Chandramouli BanerjeeMichael J Lahey
Annals of Plastic Surgery
Sadík SentürkNedim Savaci
© 2022 Meta ULC. All rights reserved