Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels

Leukemia & Lymphoma
Tom Newsom-DavisJustin Stebbing

Abstract

A 32-year-old HIV-1 positive man was diagnosed with Castleman's disease following a long history of constitutional symptoms. Primary therapy with single agent rituximab was associated with a near complete response. During this time, his KSHV (Kaposi's sarcoma-associated herpesvirus) viral load decreased and we also observed immediate, large and sustained decreases in interleukin-6 (IL-6) and tumor necrosis factor-alpha levels (TNF-alpha). This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy.

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Citations

Dec 13, 2005·Annals of Hematology·Angela CasqueroMiguel Górgolas
Jan 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T PowlesM Bower
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