Resolution of Lipoprotein Subclasses by Charge Detection Mass Spectrometry

Analytical Chemistry
Corinne A LutomskiMartin F Jarrold

Abstract

Lipoproteins are micelle-like assemblies that are key players in the pathogenesis of atherosclerosis. High-density lipoprotein (HDL), low-density lipoproteins (LDL), and very low density lipoprotein (VLDL) are the three major classes present in fasting plasma. Within each class, there is a broad size distribution with wide variations in protein and lipid content. The development of better metrics for cardiovascular risk is thought to depend on better characterization of lipoprotein subclasses. Using charge detection mass spectrometry (CDMS), the mass distributions of HDL, LDL, and VLDL have been directly measured for the first time. In the case of HDL, seven distinct subpopulations were resolved using a two-dimensional correlation of charge and mass. The resolved components are assigned to HDL particles containing different numbers of the key structural proteins apolipoprotein A-I and apolipoprotein A-II.

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Citations

Nov 14, 2019·Journal of the American Society for Mass Spectrometry·Conner C Harper, Evan R Williams
Jul 13, 2021·The Journal of Biological Chemistry·Chen ChengYongning He
Oct 30, 2020·Analytical Chemistry·James E KeenerMichael T Marty
Aug 29, 2020·Journal of the American Society for Mass Spectrometry·Elaura GustafsonDaniel E Austin
May 1, 2020·Journal of the American Society for Mass Spectrometry·Aaron R Todd, Martin F Jarrold

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