Resolution of lung injury after a single event of aspiration: a model of bilateral instillation of whole gastric fluid

The American Journal of Pathology
Joaquín D AraosGisella R Borzone

Abstract

Gastric aspiration is a high-risk condition for lung injury. Consequences range from subclinical pneumonitis to respiratory failure, with fibrosis development in some patients. Little is known about how the lung repairs aspiration-induced injury. By using a rat model of single orotracheal instillation of whole gastric contents, we studied the time course of morphological and biochemical changes during injury and resolution, and evaluated whether repair involved long-term fibrosis. Anesthetized rats received one gastric fluid instillation. At 4, 12, and 24 hours and 4 and 7 days, we performed lung histological studies and biochemical measurements in bronchoalveolar lavage fluid and lung tissue. Physiological measurements were performed at 12 to 24 hours. Long-term outcome was studied histologically at day 60. During the first 24 hours, severe peribronchiolar injury involving edema, intra-alveolar proteinaceous debris, hemorrhage, increased neutrophils and cytokines, and physiological dysfunction were observed. At days 4 and 7, an organizing pneumonia (OP) pattern developed, with foreign-body giant cells and granulomas. Lung matrix metalloproteinase 9 and 2 activities increased, with metalloproteinase-9 linked to early inflammati...Continue Reading

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Citations

Apr 27, 2018·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Jui-Chih ChangShu S Lin
Nov 8, 2019·Annals of the American Thoracic Society·Augustine S LeeJay H Ryu
Sep 2, 2018·Respiratory Research·Pedro AyalaGisella R Borzone
May 11, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pedro AyalaGisella R Borzone

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