PMID: 7027064Jan 1, 1980Paper

Resolution of scleroderma renal crisis with thrombotic microangiopathy. Case report (author's transl)

Néphrologie
K RebaizC Wolf

Abstract

Renal involvement is a common cause of death in patients with systemic sclerosis (diffuse scleroderma). The poor prognosis is due to malignant hypertension and rapid deterioration of renal function. Therefore bilateral nephrectomy followed by hemodialysis and transplantation are proposed to avoid fatal outcome. The authors describe the case of a 37 year-old male suffering from diffuse scleroderma, and who developed malignant hypertension and renal failure. The renal biopsy and biological investigations showed thrombotic microangiopathy. The plasma renin activity was in a very high range. Control of hypertension and improvement of renal function were obtained by major antihypertensive drugs, i.e. intra-muscular clonidine, propranolol and dihydralazine. 14 months later, plasma creatinine is 2 mg/100 ml and blood pressure is 140/80 mm Hg. This case and similar ones reviewed in the literature demonstrate that bilateral nephrectomy should be performed in "scleroderma renal crisis" only after failure of very potent antihypertensive therapy.

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
B M IversenE Svarstad
The American Journal of Cardiology
K H Rahn
© 2021 Meta ULC. All rights reserved