Resolve, revise, and relax: the 3 Rs of B cell repertoire adjustment.

Immunology Letters
Jean L Scholz, Michael P Cancro

Abstract

Competition for limited, cell extrinsic survival factors is a general feature of peripheral selection checkpoints involved in B lymphocyte maturation and activation. Perhaps the best-characterized example involves BLyS (B lymphocyte stimulator), which modulates the size and composition of mature naïve B cell pools, but evidence for analogous competitive checkpoints is emerging for both germinal center B cells and plasma cells. Here we discuss how deliberate alteration of BLyS levels might be used to manipulate B cell repertoire selection in order to restore self-tolerance in autoimmunity, remodel the repertoire to accommodate neo-self antigens introduced through transplantation and gene therapy, or expand repertoire diversity to reveal novel, therapeutically useful specificities.

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Citations

Sep 7, 2012·Clinical & Developmental Immunology·Valli De ReOmbretta Repetto
Feb 19, 2016·Nature Reviews. Rheumatology·Michael R Ehrenstein, Charlotte Wing
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May 13, 2014·Annals of Medicine·Andrew P Sage, Ziad Mallat
Aug 3, 2013·The Journal of Rheumatology·Maria J Leandro, Geraldine Cambridge
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Apr 11, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abigail BenitezKimberly J Payne
Nov 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yafei HuangWilli K Born

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