Resolved: EMT produces fibroblasts in the kidney

Journal of the American Society of Nephrology : JASN
Michael Zeisberg, Jeremy S Duffield

Abstract

Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.

References

Jul 1, 1995·The Journal of Cell Biology·F StrutzE G Neilson
May 1, 1994·The Journal of Cell Biology·D J LiskaP Bornstein
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·M IwanoE G Neilson
Sep 5, 2001·Nature Cell Biology·C D Stern, S E Fraser
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Junwei Yang, Youhua Liu
Jun 26, 2002·Kidney International·Maria P RastaldiGiuseppe D'Amico
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
May 22, 2003·The American Journal of Pathology·Sunfa Cheng, David H Lovett
May 11, 2005·Kidney International·Tsutomu InoueEric G Neilson
Aug 18, 2005·Kidney International·Yoshiharu NishitaniEric G Neilson
Sep 17, 2005·Circulation Research·Annika ArmulikChrister Betsholtz
Oct 28, 2005·The American Journal of Pathology·Jennifer L FaulknerJeffrey L Barnes
Nov 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Leigh A ComptonJoey V Barnett
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kevin K KimHarold A Chapman
Aug 26, 2006·Nature Clinical Practice. Nephrology·Eric G Neilson
Sep 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Norihiko SakaiShuichi Kaneko
Nov 10, 2006·The EMBO Journal·Agnès BoutetM Angela Nieto
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Guoqiang ZhangAllison A Eddy
Feb 3, 2007·The Journal of Clinical Investigation·Christo D VenkovEric G Neilson
Mar 8, 2007·Kidney International·M S Simonson
Jun 15, 2007·The Journal of Biological Chemistry·Michael ZeisbergRaghu Kalluri
Jul 31, 2007·Nature Medicine·Elisabeth M ZeisbergRaghu Kalluri
Sep 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adam Lacy-HulbertRichard O Hynes
Nov 27, 2007·The Journal of Clinical Investigation·Debra F HigginsVolker H Haase
Apr 25, 2008·Journal of the American Society of Nephrology : JASN·Alexandre HertigYi-Chun Xu-Dubois
May 2, 2008·Histochemistry and Cell Biology·Nicolas PicardMichel Le Hir
May 16, 2008·Journal of the American Society of Nephrology : JASN·Matthew J VitaloneBrian J Nankivell
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Michael Zeisberg, Raghu Kalluri
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DjamaliS Reese
Nov 7, 2008·Journal of the American Society of Nephrology : JASN·Elisabeth M ZeisbergRaghu Kalluri
Apr 15, 2009·Clinical and Experimental Nephrology·Tsutomu InoueHiromichi Suzuki

❮ Previous
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Citations

Nov 28, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter Y ChuangJohn C He
Aug 17, 2011·Cell and Tissue Research·Rosemarie M CarewPhillip Kantharidis
Feb 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ivica GrgicBenjamin D Humphreys
May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tammo OstendorfJürgen Floege
Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kavita S Hodgkins, H William Schnaper
Apr 25, 2013·Cancer Letters·Pierre GalichonAlexandre Hertig
Oct 20, 2011·Nature Reviews. Nephrology·Youhua Liu
Mar 23, 2011·Nature Reviews. Nephrology·Johan M LorenzenThomas Thum
Sep 4, 2013·Nature Reviews. Nephrology·Liangxiang Xiao, Youhua Liu
Nov 26, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ana Carina FerreiraFernando Nolasco
Nov 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rachel M McLoughlin, Nicholas Topley
Oct 26, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicolas Pallet
May 5, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stuart W SmithCaroline O S Savage
Jun 27, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sydney C W Tang, Kar Neng Lai
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter Boor, Jürgen Floege
Jan 26, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre GalichonEric Rondeau
Dec 6, 2011·QJM : Monthly Journal of the Association of Physicians·B Conway, J Hughes
Dec 1, 2012·Current Opinion in Rheumatology·Cécile Fligny, Jeremy S Duffield
Nov 8, 2012·Current Opinion in Nephrology and Hypertension·Michal Herman-EdelsteinUzi Gafter
Feb 15, 2012·Journal of Gastroenterology and Hepatology·Keiko IwaisakoTatiana Kisseleva
Apr 13, 2011·Molecular and Cellular Biology·R Grant RoweStephen J Weiss
Apr 12, 2012·American Journal of Physiology. Renal Physiology·Roderick J Tan, Youhua Liu
Dec 14, 2011·Journal of Biomedicine & Biotechnology·Catherine E WinbanksTim D Hewitson
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Jan 22, 2011·Journal of Translational Medicine·José M López-NovoaFrancisco J López Hernández
Apr 8, 2011·Fibrogenesis & Tissue Repair·Pierre Galichon, Alexandre Hertig
Jan 4, 2013·Fibrogenesis & Tissue Repair·Katrien Van BenedenLeo A van Grunsven
Jul 18, 2012·Proceedings of the American Thoracic Society·Boris Hinz
Sep 14, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivonne Loeffler, Gunter Wolf
Sep 28, 2013·International Urology and Nephrology·Alvaro C UceroAlberto Ortiz
Oct 25, 2012·Annual Review of Pathology·Jeremy S DuffieldThomas A Wynn
Dec 22, 2011·International Journal of Inflammation·Yasuhiro Yoshimatsu, Tetsuro Watabe
Aug 26, 2011·Cell and Tissue Research·Laurens A van Meeteren, Peter ten Dijke
Dec 3, 2014·Expert Reviews in Molecular Medicine·Jose M Muñoz-FelixJose M Lopez-Novoa
Jan 15, 2011·Journal of Cell Communication and Signaling·Andrew Leask
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Gabriela CampanholleJeremy S Duffield
Dec 15, 2010·Clinical and Experimental Nephrology·Takashi WadaKengo Furuichi
Aug 21, 2015·Connective Tissue Research·Jacqueline Banyard, Diane R Bielenberg
Oct 16, 2015·Molecular Medicine Reports·Tianming LiuYaguang Weng

❮ Previous
Next ❯

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