Resolvin D1 protects against sepsis-induced cardiac injury in mice.

BioFactors
Menglong WangJun Wan

Abstract

Increased inflammation is the key mechanism that mediates sepsis induced cardiac injury. Resolvin D1 (RvD1), a bioactive lipid mediator synthesized from docosahexaenoic acid, can attenuate the severity of many inflammation-related diseases through anti-inflammatory and pro-resolving properties. However, the protective role of RvD1 in sepsis induced cardiac injury remains unclear. Mice were randomly divided into three groups: the control group, LPS group and RvD1 + LPS group. LPS (10 mg/kg, i.p.) was used to establish a sepsis-induced cardiac injury model. RvD1 (5 ug/kg, i.p.) was injected 30 min before LPS injection. RvD1 treatment significantly attenuated the deteriorated cardiac function and cardiac injury induced by LPS, as evidenced by the improved left ventricular ejection fraction, serum levels of cardiac injury markers and severity of cardiomyocyte apoptosis. In addition, RvD1 treatment significantly attenuated the infiltration of pro-inflammatory M1 macrophages and expression of inflammatory cytokines in the heart. Mechanistically, the attenuated activation of NK-κB and MAPK signaling mediated the anti-inflammatory and antiapoptotic effects of RvD1. In addition, LPS-induced infiltration of neutrophils and M1 macrophages...Continue Reading

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Nov 30, 2020·BioFactors·Shayna Sandhaus, Andrew G Swick
Feb 23, 2021·Frontiers in Immunology·Yu SawadaMotonobu Nakamura
Jul 3, 2021·Antioxidants·Andrea Gila-DiazDavid Ramiro-Cortijo
Aug 18, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Francisco Olivares-SilvaGuillermo Díaz-Araya

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