Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma

Biochemical and Biophysical Research Communications
Haruka AokiMasatomo Mori

Abstract

Resolvin E1 (RvE1; 5S, 12R, 18R-trihydroxyeicosapentaenoic acid) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It has been recently shown that RvE1 is involved in the resolution of inflammation. However, it is not known whether RvE1 is involved in the resolution of asthmatic inflammation. To investigate the anti-inflammatory effect of RvE1 in asthma, a murine model of asthma was studied. After RvE1 was administered to mice intraperitoneally, there were decreases in: airway eosinophil and lymphocyte recruitment, specific Th2 cytokine, IL-13, ovalbumin-specific IgE, and airway hyperresponsiveness (AHR) to inhaled methacholine. Moreover, RvE1-treated mice had significantly lower mucus scores compared to vehicle-treated mice based on the number of goblet cells stained with periodic acid-schiff (PAS). These findings provide evidence that RvE1 is a pivotal counterregulatory signal in allergic inflammation and offer novel multi-pronged therapeutic approaches for human asthma.

References

Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Aug 13, 1998·The European Respiratory Journal·P J Barnes, I M Adcock
Apr 1, 2000·Australian Family Physician·J Burdon
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·J C LaporteS A Shore
Dec 20, 2002·Nature·Carl Nathan
Feb 6, 2004·The New England Journal of Medicine·Steven D FreedmanBrian P O'Sullivan
May 12, 2004·Nature Reviews. Drug Discovery·Derek W GilroyAdriano G Rossi
Jul 20, 2004·Nature Medicine·Nobuaki MiyaharaErwin W Gelfand
Mar 9, 2005·The Journal of Experimental Medicine·Makoto AritaCharles N Serhan
Apr 26, 2005·American Journal of Respiratory and Critical Care Medicine·Nobuaki MiyaharaErwin W Gelfand
May 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Makoto AritaCharles N Serhan
Oct 12, 2005·The Journal of Biological Chemistry·Amiram ArielCharles N Serhan
Dec 22, 2005·Nature Immunology·Peter M Henson
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian TaubeErwin W Gelfand
Jun 8, 2006·The Journal of Biological Chemistry·Makoto AritaCharles N Serhan
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Hamida Hammad, Bart N Lambrecht

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Citations

Oct 22, 2011·Cancer Metastasis Reviews·Naveena B JanakiramChinthalapally V Rao
Dec 10, 2009·Clinical Reviews in Allergy & Immunology·Lefkothea-Stella KremmydaPhilip C Calder
Nov 28, 2012·Clinical Reviews in Allergy & Immunology·Juan R Velazquez, Luis M Teran
May 15, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Driss El KebirJános G Filep
Nov 13, 2009·The Journal of Biological Chemistry·Taisuke OhiraCharles N Serhan
Jul 14, 2010·TheScientificWorldJournal·Troy Carlo, Bruce D Levy
Apr 27, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yulia Y TyurinaValerian E Kagan
May 15, 2013·Respiratory Research·Tara M NordgrenDebra J Romberger
Dec 10, 2013·Annual Review of Physiology·Bruce D Levy, Charles N Serhan
Mar 4, 2014·Journal of Inflammation·Nir ErdinestAbraham Solomon
Apr 20, 2014·BMC Pulmonary Medicine·Hongyun ZhaoMaureen R Horton
Mar 13, 2012·Annual Review of Nutrition·Michael J Zhang, Matthew Spite
Feb 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya MiyaharaMichael S Conte
Oct 15, 2010·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Jan 27, 2016·Nutrition Research Reviews·Aishwarya KumarMartin R Lindley
Mar 19, 2013·Prostaglandins & Other Lipid Mediators·Antonio Recchiuti
Oct 16, 2012·Prostaglandins & Other Lipid Mediators·Anna Maria Giudetti, Raffaele Cagnazzo
Aug 30, 2012·Clinics in Chest Medicine·Bruce D LevyCharles N Serhan
Feb 14, 2012·Prostaglandins & Other Lipid Mediators·Karsten H WeylandtBertram Wiedenmann
Jul 19, 2011·Progress in Lipid Research·Hemant PoudyalLindsay Brown
Sep 4, 2010·The American Journal of Pathology·Charles N Serhan
Aug 17, 2010·Biochemical and Biophysical Research Communications·Haruka AokiMasatomo Mori
Sep 10, 2009·Prostaglandins & Other Lipid Mediators·Hiroyuki SekiMakoto Arita
Nov 8, 2015·European Journal of Pharmacology·Melody G Duvall, Bruce D Levy
Jul 15, 2009·British Journal of Pharmacology·Payal Kohli, Bruce D Levy
Jun 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P C Calder
Aug 13, 2013·Periodontology 2000·Marcelo O Freire, Thomas E Van Dyke
Apr 24, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L G WoodP M Hansbro
Aug 21, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MorinÉ Rousseau
Jul 24, 2014·Cell Biology International·Qing QuGuo-Huang Fan
Jul 21, 2015·Biochemical and Biophysical Research Communications·Bruno S HerreraThomas E Van Dyke
Jun 30, 2011·The Biochemical Journal·Gabrielle Fredman, Charles N Serhan
Jan 19, 2013·Biochemical Pharmacology·Ha-Na Lee, Young-Joon Surh
Oct 5, 2010·Progress in Lipid Research·Mohib Uddin, Bruce D Levy
Feb 7, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Tara M NordgrenDebra J Romberger
Apr 22, 2015·Trends in Endocrinology and Metabolism : TEM·Karim El KholyThomas E Van Dyke
Oct 24, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Troy Carlo, Bruce D Levy
Jan 13, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Jun Miyata, Makoto Arita
Mar 13, 2014·The Journal of Allergy and Clinical Immunology·Stacy Gelhaus WendellFernando Holguin
Jun 20, 2016·International Immunopharmacology·Yi GaoLiu Jifang

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