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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays

PLoS Genetics

Sep 5, 2008

Nils HomerD W Craig

Abstract

We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop a theoretical framework for detecting an individual's presence withi...read more

Mentioned in this Paper

Genome-Wide Association Study
In Silico
Short Tandem Repeat
Genome
DNA, Mitochondrial
Nucleic Acid Hybridization Procedure
Medical Genetics Specialty
Human Genetics
Genomics
Genomic DNA
17
8
1
506
1
Paper Details
References
  • References23
  • Citations265
123
  • References23
  • Citations265
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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays

PLoS Genetics

Sep 5, 2008

Nils HomerD W Craig

PMID: 18769715

DOI: 10.1371/journal.pgen.1000167

Abstract

We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop a theoretical framework for detecting an individual's presence withi...read more

Mentioned in this Paper

Genome-Wide Association Study
In Silico
Short Tandem Repeat
Genome
DNA, Mitochondrial
Nucleic Acid Hybridization Procedure
Medical Genetics Specialty
Human Genetics
Genomics
Genomic DNA
17
8
1
506
1

Feeds With Similar Papers

Forensic Psychiatry

Forensic psychiatry includes the relationship between psychiatric abnormalities and legal violations and crimes. Discover the latest research on forensic psychiatry here.

Open Access Genomics Journals

Discover the latest genomics research in this collection of the top open access genomics journals.

Related Papers

PLoS Genetics

Needles in the haystack: identifying individuals present in pooled genomic data

PLoS GeneticsOctober 3, 2009
Rosemary BraunKenneth Buetow
Paper Details
References
  • References23
  • Citations265
123
  • References23
  • Citations265
12345...

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