Resolving powers of >7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry

The Analyst
Brandon G SantiagoGary L Glish

Abstract

Differential ion mobility spectrometry (DIMS) separations are described using similar terminology to liquid chromatography, capillary electrophoresis, and drift tube ion mobility spectrometry. The characterization and comparison of all these separations are typically explained in terms of resolving power, resolution, and/or peak capacity. A major difference between these separations is that DIMS separations are in space whereas the others are separations in time. However, whereas separations in time can, in theory, be extended infinitely, separations in space, such as DIMS separations, are constrained by the physical dimensions of the device. One method to increase resolving power of DIMS separations is to use helium in the DIMS carrier gas. However, ions have a greater mobility in helium which causes more ions to be neutralized due to collisions with the DIMS electrodes or electrode housing, i.e. the space constraints. This neutralization of ions can lead to the loss of an entire peak, or peaks, from a DIMS scan. To take advantage of the benefits of helium use while reducing ion losses, linked scans were developed. During a linked scan the amount of helium present in the DIMS carrier gas is decreased as the compensation field ...Continue Reading

References

Dec 15, 2004·Analytical Chemistry·Alexandre A ShvartsburgRichard D Smith
Jun 2, 2006·Analytical Chemistry·Alexandre A ShvartsburgRichard D Smith
Nov 16, 2006·Analytical Chemistry·Erkinjon G NazarovGary A Eiceman
Aug 29, 2007·Journal of the American Society for Mass Spectrometry·Alexandre A Shvartsburg, Richard D Smith
Nov 7, 2008·Analytical Chemistry·Alexandre A Shvartsburg, Richard D Smith
Nov 27, 2009·Analytical Chemistry·Alexandre A ShvartsburgRichard D Smith
Feb 4, 2010·Analytical Chemistry·Bradley B SchneiderErkinjon G Nazarov
Feb 16, 2010·Analytical Chemistry·Alexandre A ShvartsburgRichard D Smith
Jul 30, 2010·Analytical Chemistry·Alexandre A ShvartsburgRichard D Smith
Dec 2, 2010·Analytical Chemistry·Alexandre A Shvartsburg, Richard D Smith
Aug 26, 2011·Analytical Chemistry·Alexandre A ShvartsburgHelen J Cooper
Jan 25, 2013·Journal of the American Society for Mass Spectrometry·Alexandre A ShvartsburgRichard D Smith
Jul 6, 2014·Journal of the American Society for Mass Spectrometry·Samantha L IsenbergGary L Glish
Jul 8, 2015·Journal of the American Society for Mass Spectrometry·Brandon G SantiagoGary L Glish

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Citations

Oct 19, 2016·Journal of the American Society for Mass Spectrometry·Matthew T Campbell, Gary L Glish
Apr 9, 2019·Analytical and Bioanalytical Chemistry·Ansgar T KirkStefan Zimmermann
Oct 13, 2017·Journal of Separation Science·Valentina D'AtriDavy Guillarme
Mar 20, 2021·Analytica Chimica Acta·Dylan H Ross, Libin Xu
Jun 28, 2017·Journal of the American Society for Mass Spectrometry·Brandon G SantiagoGary L Glish

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