Resolving relaxometry and diffusion properties within the same voxel in the presence of crossing fibres by combining inversion recovery and diffusion-weighted acquisitions

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Silvia De SantisYaniv Assaf

Abstract

A comprehensive image-based characterization of white matter should include the ability to quantify myelin and axonal attributes irrespective of the complexity of fibre organization within the voxel. While progress has been made with diffusion MRI-based approaches to measure axonal morphology, to date available myelin metrics simply assign a single scalar value to the voxel, reflecting some form of average of its constituent fibres. Here, a new experimental framework that combines diffusion MRI and relaxometry is introduced. It provides, for the first time, the ability to assign to each unique fibre system within a voxel, a unique value of the longitudinal relaxation time, T1, which is largely influenced by the myelin content. We demonstrate the method through simulations, in a crossing fibres phantom, in fixed brains and in vivo. The method is capable of recovering unique values of T1 for each fibre population. The ability to extract fibre-specific relaxometry properties will provide enhanced specificity and, therefore, sensitivity to differences in white matter architecture, which will be invaluable in many neuroimaging studies. Further the enhanced specificity should ultimately lead to earlier diagnosis and access to treatme...Continue Reading

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Citations

Apr 7, 2016·Annual Review of Neuroscience·Brian A Wandell
Mar 13, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eddy SolomonLucio Frydman
Mar 21, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daeun KimJustin P Haldar
Oct 16, 2018·NMR in Biomedicine·Dmitry S NovikovValerij G Kiselev
Mar 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorDaniel C Alexander
Aug 31, 2017·Scientific Reports·D C DeanA L Alexander
Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Björn LampinenMarkus Nilsson
Oct 13, 2018·Scientific Reports·Jana HutterJoseph V Hajnal
Mar 25, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Miguel Molina-RomeroBjoern H Menze
Dec 21, 2016·Brain Plasticity·Jessica DuboisGhislaine Dehaene-Lambertz
Dec 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marc GolubRita Gouveia Nunes
Dec 11, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexis ReymbautDaniel Topgaard
Dec 15, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Merlin J FairKawin Setsompop
Oct 24, 2020·Journal of Neuroscience Methods·Dmitry S Novikov
Mar 23, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilana R LeppertChristine L Tardif
Nov 14, 2020·Investigative Radiology·Valerij G KiselevPeter Gall
May 4, 2020·NeuroImage·Francesco GrussuClaudia A M Gandini Wheeler-Kingshott
Jun 3, 2021·International Journal of Molecular Sciences·Koji KamagataShigeki Aoki
Jul 14, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michiel CottaarSaad Jbabdi
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorJana Hutter

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Software Mentioned

CHARMED
ExploreDTI
UNDISTORT
Matlab

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