Resolving the Ionotropic P2X4 Receptor Mystery Points Towards a New Therapeutic Target for Cardiovascular Diseases.

International Journal of Molecular Sciences
Bruno Bragança, Paulo Correia-de-Sá

Abstract

Adenosine triphosphate (ATP) is a primordial versatile autacoid that changes its role from an intracellular energy saver to a signaling molecule once released to the extracellular milieu. Extracellular ATP and its adenosine metabolite are the main activators of the P2 and P1 purinoceptor families, respectively. Mounting evidence suggests that the ionotropic P2X4 receptor (P2X4R) plays pivotal roles in the regulation of the cardiovascular system, yet further therapeutic advances have been hampered by the lack of selective P2X4R agonists. In this review, we provide the state of the art of the P2X4R activity in the cardiovascular system. We also discuss the role of P2X4R activation in kidney and lungs vis a vis their interplay to control cardiovascular functions and dysfunctions, including putative adverse effects emerging from P2X4R activation. Gathering this information may prompt further development of selective P2X4R agonists and its translation to the clinical practice.

References

Jul 31, 1990·Biochemical and Biophysical Research Communications·P MilnerG Burnstock
May 1, 1984·The American Journal of Cardiology·B BelhassenS Laniado
Oct 1, 1995·Pflügers Archiv : European journal of physiology·J A Brock, D F Van Helden
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·F SotoW Stühmer
Sep 1, 1996·The American Journal of Physiology·C GuibertJ P Savineau
Feb 1, 1997·British Journal of Pharmacology·R A QasabianD J Williamson
Oct 27, 1997·Journal of Neurophysiology·R StoopR A North
Jan 14, 1999·Neuropharmacology·K J MillerP P Humphrey
Aug 10, 1999·European Journal of Pharmacology·B R BianchiT van Biesen
Feb 29, 2000·British Journal of Pharmacology·C A JonesP P Humphrey
Mar 16, 2000·The Journal of Physiology·C E ClarkeH J Meadows
Aug 30, 2001·European Journal of Clinical Investigation·G G BelzU Osowski
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B HuB T Liang
Sep 6, 2002·Journal of Medicinal Chemistry·Kenneth A JacobsonMichael Williams
Nov 19, 2002·Molecular Pharmacology·Catherine Vial, Richard J Evans
Apr 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kimiko YamamotoJoji Ando
Sep 13, 2003·The Journal of Biological Chemistry·Mu-Lan HeStanko S Stojilkovic
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Alexander YangBruce T Liang
Jul 1, 2004·Circulation·Jay N CohnKenneth A Jamerson
Sep 24, 2004·The New England Journal of Medicine·Nagesh S AnavekarMarc A Pfeffer
Jan 5, 2005·Toxicology and Applied Pharmacology·Claudio CoddouJ Pablo Huidobro-Toro
Mar 16, 2005·Annals of Internal Medicine·Ramachandran S VasanRalph B D'Agostino
May 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anand S PatelMichael Koval
Jul 8, 2005·Journal of the American Society of Nephrology : JASN·Scott S WildmanRobert J Unwin
Mar 15, 2006·The Journal of Biological Chemistry·Samuel J Fountain, R Alan North
May 19, 2006·Pflügers Archiv : European journal of physiology·Terrance M EganZhiyuan Li
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joan A SimFrancois Rassendren
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Verónica A CampanucciColin A Nurse
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jian-Bing ShenBruce T Liang
Feb 1, 2008·Journal of the American Society of Nephrology : JASN·Scott S P WildmanRobert J Unwin
Mar 28, 2008·Purinergic Signalling·David Erlinge, Geoffrey Burnstock
Jul 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dmitry SoninBruce T Liang

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Citations

Oct 31, 2020·British Journal of Pharmacology·Peter IllesFrancesco Di Virgilio
Apr 27, 2021·Frontiers in Immunology·Jean M KanellopoulosDavid M Ojcius
Aug 28, 2021·International Journal of Molecular Sciences·Raquel Pérez-Sen, Esmerilda G Delicado

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